Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects

Abstract

Objective:

Constipation is a common problem in the elderly. Dietary fibre is recommended for its treatment. The aim was to examine whether yoghurt containing galacto-oligosaccharides (GOS), prunes and linseed relieve constipation in elderly subjects.

Design:

A randomized, double-blinded, cross-over study.

Setting:

Free-living subjects.

Subjects:

A group of 43 elderly subjects with self-reported constipation (mean age 76 years, range 61–92 years, 32 females, 11 males).

Interventions:

The study consisted of a 2-week baseline period and 2, 3-week dietary interventions, with a 2-week wash-out period between the interventions. During the interventions, the subjects ingested, in random order, 260 g/day of either control yoghurt or test yoghurt containing GOS (12 g/day), prunes (12 g/day) and linseed (6 g/day). The use of laxatives was controlled and only allowed after 2 days without defecation.

Results:

Defecation frequency was 5.7 times/week during the baseline period. During the test yoghurt period, defecation frequency was higher (8.0 vs 7.1 times/week, P=0.011), defecation was easier (on the scale 0–3, 1.3 vs 1.5, P=0.010), and there was a tendency towards softer stools (on the scale 0–3, 2.1 vs 2.2, P=0.059) compared with the control yoghurt period. The subjects felt that the test yoghurt relieved constipation more effectively than the control yoghurt (P=0.005). The sum of gastrointestinal symptoms did not differ between the interventions. The use of laxatives remained constant throughout the study.

Conclusions:

Daily intake of yoghurt containing GOS, prunes and linseed reduced the severity of constipation in elderly subjects with mild constipation.

Sponsorship:

Valio Ltd, R&D.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  • Adolfsson O, Meydani SN, Russell RM (2004). Yogurt and gut function. Am J Clin Nutr 80, 245–256.

    Article  CAS  Google Scholar 

  • Attar A, Lémann M, Ferguseon A, Halphen M, Boutron M-C, Flourié B et al. (1999). Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut 44, 226–230.

    Article  CAS  Google Scholar 

  • Boehm G, Lidestri M, Casetta P, Jelinek J, Negretti F, Stahl B et al. (2002). Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Arch Dis Child Fetal Neonatal Ed 86, F178–F181.

    Article  CAS  Google Scholar 

  • Bouhnik Y, Flourié B, D'Agay-Abensour L, Pochart P, Gramet G, Durand M et al. (1997). Administration of transgalacto-oligosaccharides increases fecal bifidobacteria and modifies colonic fermentation metabolism in healthy humans. J Nutr 127, 444–448.

    Article  CAS  Google Scholar 

  • Cummings JH, Macfarlane GT, Englyst HN (2001). Prebiotic digestion and fermentation. Am J Clin Nutr 73 (Suppl 2), 415S–420S.

    Article  CAS  Google Scholar 

  • Cunnane SC, Hamadeh MJ, Liede AC, Thompson LU, Wolever TMS, Jenkins DJA. (1995). Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 61, 62–68.

    Article  CAS  Google Scholar 

  • Deguchi Y, Matsumoto K, Ito A, Watanuki M (1997). Effects of beta-1-4 galacto-oligosaccharides administration on defecation of healthy volunteers with constipation tendency. Jpn J Nutr 55, 13–22.

    Article  CAS  Google Scholar 

  • Delzenne NM (2003). Oligosaccharides: state of the art. Proc Nutr Soc 62, 177–182.

    Article  CAS  Google Scholar 

  • Ferrer FP, Boyd LJ (1955). Effect of yogurt with prune whip on constipation. Am J Dig Dis 9, 272–273.

    Google Scholar 

  • Gopal PK, Prasad J, Gill HS (2003). Effects of the consumption of Bifidobacterium lactis HN019 (DR10TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutr Res 23, 1313–1328.

    Article  CAS  Google Scholar 

  • Hull C, Greco RS, Brooks DL (1980). Alleviation of constipation in the elderly by dietary fiber supplementation. J Am Geriatr Soc 28, 410–414.

    Article  CAS  Google Scholar 

  • Ito M, Deguchi Y, Miyamoro A, Matsumoto K, Kikuchi H, Matsumoto K, Kobayashi Y, Yajima T, Kan T (1990). Effects of administration of galactooligosaccharides on the human faecal microflora, stool weight and abdominal sensation. Microbial Ecol 3, 285–292.

    Google Scholar 

  • Jäkälä E, Korpela R, Mykkänen H (1994). Validity and reliability of a short interview method in measuring the intake of dietary fibre. Scand J Nutr 38 (Suppl 9), 5 (abstract).

    Google Scholar 

  • Knol J, Scholtens P, Kafka C, Steenbakkers J, Gro S, Helm K et al. (2005). Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants. J Pediatr Gastroenterol Nutr 40, 36–42.

    Article  CAS  Google Scholar 

  • Kunz C, Rudloff S (1993). Biological functions of oligosaccharides in human milk. Acta Paediatr 82, 903–912.

    Article  CAS  Google Scholar 

  • Kunz C, Rudloff S, Baier W, Klein N, Strobel S (2000). Oligosaccharides in human milk: structural, functional, and metabolic aspects. Annu Rev Nutr 20, 699–722.

    Article  CAS  Google Scholar 

  • Livesey G (2001). Tolerance of low-digestible carbohydrates: a general view. Br J Nutr 85 (Suppl 1), S7–S16.

    Article  CAS  Google Scholar 

  • McVeagh P, Miller JB (1997). Human milk oligosaccharides: only the breast. J Paediatr Child Health 33, 281–286.

    Article  CAS  Google Scholar 

  • Moro G, Minoli I, Mosca M, Fanaro S, Jelinek J, Stahl B, Boehm G (2002). Dosage-related bifidogenic effects of galacto- and fructo-oligosaccharides in formula-fed infants. J Pediatr Gast Nutr 34, 291–295.

    Article  CAS  Google Scholar 

  • Muller-Lissner SA, Kaatz V, Brandt W, Keller J, Layer P (2005a). The perceived effect of various foods and beverages on stool consistency. Eur J Gastroenterol Hepatol 17, 109–112.

    Article  Google Scholar 

  • Muller-Lissner SA, Kamm MA, Scarpignato C, Wald A (2005b). Myths and misconceptions about chronic constipation. Am J Gastroenterol 100, 232–242.

    Article  Google Scholar 

  • Rinne MM, Gueimonde M, Kalliomäki M, Hoppu U, Salminen SJ, Isolauri E (2005). Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota. FEMS Immunol Med Microbiol 43, 59–65.

    Article  CAS  Google Scholar 

  • Schaefer DC, Cheskin LJ (1998). Constipation in the elderly. Am Fam Physician 58, 907–914.

    CAS  PubMed  Google Scholar 

  • Shitara A (1988). Effect of 4′-galactosyl-lactose on constipated old patients and intestinal bacteria. Med Biol 117, 371–373.

    Google Scholar 

  • Stacewicz-Sapuntzakis M, Bowen PE, Hussain EA, Damayanti-Wood BI, Farnsworth NR (2001). Chemical composition and potential health effects of prunes: a functional food? Crit Rev Food Sci Nutr 41, 251–286.

    Article  CAS  Google Scholar 

  • Stern FH (1966). Constipation - an omnipresent symptom: effect of a preparation containing prune concentrate and cascarin. J Am Geriatr Soc 14, 1153–1155.

    Article  CAS  Google Scholar 

  • Suarez FL, Springfield J, Furne JK, Lohrmann TT, Kerr PS, Levitt MD (1999). Gas production in human ingesting a soybean flour derived from beans naturally low in oligosaccharides. Am J Clin Nutr 69, 135–139.

    Article  CAS  Google Scholar 

  • Taylor R (1990). Management of constipation. High fibre diets work. Br Med J 300, 1063–1064.

    Article  CAS  Google Scholar 

  • Teuri U, Korpela R (1998). Galacto-oligosaccharides relieve constipation in elderly people. Ann Nutr Metab 42, 319–327.

    Article  CAS  Google Scholar 

  • Teuri U, Korpela R, Saxelin M, Montonen L, Salminen S (1998). Increased fecal frequency and gastrointestinal symptoms following ingestion of galacto-oligosaccharide-containing yogurt. J Nutr Sci Vitaminol 44, 465–471.

    Article  CAS  Google Scholar 

  • Tinker LF, Schneeman BO, Davis PA, Gallaher DD, Waggoner CR (1991). Consumption of prunes as a source of dietary fiber in men with mild hypercholesterolemia. Am J Clin Nutr 53, 1259–1265.

    Article  CAS  Google Scholar 

  • van Dokkum W, Wezendonk B, Srikumar TS, van den Heuvel EG (1999). Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects. Eur J Clin Nutr 53, 1–7.

    Article  CAS  Google Scholar 

  • Zaraté S, López-Leiva MH (1990). Oligosaccharide formation during enzymatic lactose hydrolysis: a literature review. J Food Prot 53, 262–268.

    Article  Google Scholar 

Download references

Acknowledgements

We thank Tuija Poussa, MSc, for statistical advice and to Mimi Ponsonby, MA, for editing the English.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R Korpela.

Additional information

Guarantor: R Korpela.

Contributors: US, RN and RK contributed to the design of the study, US conducted the recruitment, intervention and data collection, and LP wrote the paper with the co-operation of the other authors.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sairanen, U., Piirainen, L., Nevala, R. et al. Yoghurt containing galacto-oligosaccharides, prunes and linseed reduces the severity of mild constipation in elderly subjects. Eur J Clin Nutr 61, 1423–1428 (2007). https://doi.org/10.1038/sj.ejcn.1602670

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ejcn.1602670

Keywords

This article is cited by

Search

Quick links