Replacing sugar with low-calorie sweeteners is a common strategy for facilitating weight control. By providing sweet taste without calories, intense sweeteners help lower energy density of beverages and some foods. Reduced dietary energy density should result in lower energy intakes – but are the energy reduction goals, in fact, achieved? The uncoupling of sweetness and energy, afforded by intense sweeteners, has been the focus of numerous studies over the past two decades. There are recurring arguments that intense sweeteners increase appetite for sweet foods, promote overeating, and may even lead to weight gain. Does reducing energy density of sweet beverages and foods have a measurable impact on appetite and energy intakes, as examined both in short-term studies and over a longer period? Can reductions in dietary energy density achieved with intense sweeteners really affect body weight control? This paper reviews evidence from laboratory, clinical and epidemiological studies in the context of current research on energy density, satiety and the control of food intake.
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Scientific Reports Open Access 16 November 2016
Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies
International Journal of Obesity Open Access 14 September 2015
European Journal of Nutrition Open Access 09 September 2015
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Almiron-Roig E, Chen Y, Drewnowski A (2003). Liquid calories and the failure of satiety: how good is the evidence? Obes Rev 4, 201–212.
Almiron-Roig E, Drewnowski A (2003). Hunger, thirst, and energy intakes following consumption of caloric beverages. Physiol Behav 79, 767–773.
Almiron-Roig E, Flores SY, Drewnowski A (2004). No difference in satiety or in subsequent energy intakes between a beverage and a solid food. Physiol Behav 82, 671–677.
Anderson GH, Saravis S, Schacher R, Zlotkin S, Leiter LA (1989). Aspartame: effect on lunch-time food intake, appetite and hedonic response in children. Appetite 13, 93–103.
Bell EA, Castellanos VH, Pelkman CL, Thorwart ML, Rolls BJ (1998). Energy density of foods affects energy intake in normal-weight women. Am J Clin Nutr 67, 412–420.
Bellisle F, Altenburg de Assis MA, Fieux B, Preziosi P, Galan P, Guy-Grand B et al. (2001). Use of ‘light’ foods and drinks in French adults: biological, anthropometric and nutritional correlates. J Hum Nutr Diet 14, 191–206.
Bellisle F, Perez C (1994). Low-energy substitutes for sugars and fats in the human diet: impact on nutritional regulation. Neurosci Biobehav Rev 18, 197–205.
Beridot-Therond ME, Arts I, Fantino M, de La Guéronière V (1998). Short-term effects of the flavour of drinks on ingestive behaviours in man. Appetite 31, 67–81.
Bernard C (1856). Introduction à l’étude de la médecine expérimentale. Baillère: Paris. Ref Type: Serial (Book, Monograph).
Berthoud H, Seeley R (1999). Neural and Metabolic Control of Macronutrient Intake. CRC Press: Boca Raton, FL.
Birch LL (1987). The acquisition of food acceptance patterns in children. In: Boakes RA (ed). Eating Habits, pp 107–130.
Birch LL (1992). Children's preferences for high-fat foods. Nutr Rev 50, 249–255.
Birch LL, Deysher M (1986). Caloric compensation and sensory specific satiety: evidence for self regulation of food intake by young children. Appetite 7, 323–331.
Birch LL, McPhee L, Sullivan S (1989). Children's food intake following drinks sweetened with sucrose or aspartame: time course effects. Physiol Behav 45, 387–395.
Black RM, Leiter LA, Anderson GH (1993). Consuming aspartame with and without taste: differential effects on appetite and food intake of young adult males. Physiol Behav 53, 459–466.
Black RM, Tanaka P, Leiter LA, Anderson GH (1991). Soft drinks with aspartame: effect on subjective hunger, food selection, and food intake of young adult males. Physiol Behav 49, 803–810.
Blackburn GL, Kanders BS, Lavin PT, Keller SD, Whatley J (1997). The effect of aspartame as part of a multidisciplinary weight-control program on short- and long-term control of body weight. Am J Clin Nutr 65, 409–418.
Blundell JE, Green SM (1996). Effect of sucrose and sweeteners on appetite and energy intake. Int J Obes Relat Metab Disord 20 (Suppl 2), S12–S17.
Blundell JE, Green S, Burley V (1994). Carbohydrates and human appetite. Am J Clin Nutr 59 (Suppl), 728S–734S.
Blundell JE, Hill AJ (1986). Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet 1, 1092–1093.
Blundell JE, King NA (1996). Overconsumption as a cause of weight gain: behavioural–physiological interactions in the control of food intake (appetite). Ciba Found Symp 201, 138–154.
Blundell JE, Rogers PJ, Hill AJ (1988). Uncoupling sweetness and calories: methodological aspects of laboratory studies on appetite control. Appetite 11 (Suppl 1), 54–61.
Booth D (1987). Evaluation of the usefulness of low-calorie sweeteners in weight control. In: Developments in Sweeteners. Elsevier Applied Science: London, pp 287–316.
Bray GA, Nielsen SJ, Popkin BM (2004). Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79, 537–543.
Cannon WB (1932). The Wisdom of the Body. WW Norton: New York.
Canty DJ, Chan MM (1991). Effects of consumption of caloric vs noncaloric sweet drinks on indices of hunger and food consumption in normal adults. Am J Clin Nutr 53, 1159–1164.
Chen LN, Parham ES (1991). College students’ use of high-intensity sweeteners is not consistently associated with sugar consumption. J Am Diet Assoc 91, 686–690.
Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D (2004). Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 287, E297–E304.
Davidson TL, Swithers SE (2004). A Pavlovian approach to the problem of obesity. Int J ObesRelat Metab Disord 28, 933–935.
de Castro JM (2004). Dietary energy density is associated with increased intake in free-living humans. J Nutr 134, 335–341.
De La Hunty A, Gibson S, Ashwell M (2006). A review of the effectiveness of aspartame in helping with weight control. Br Nutr Found Nutr Bull 31, 115–128.
DellaValle DM, Roe LS, Rolls BJ (2005). Does the consumption of caloric and non-caloric beverages with a meal affect energy intake? Appetite 44, 187–193.
DiMeglio DP, Mattes RD (2000). Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes Relat Metab Disord 24, 794–800.
DiSogra L, Glanz K, Rogers T (1990). Working with community organizations for nutrition intervention. Health Educ Res 5, 459–465.
Drewnowski A (1998a). Energy density, palatability, and satiety: implications for weight control. Nutr Rev 56, 347–353.
Drewnowski A (1998b). Palatability and satiety: models and measures. Annales Nestle 5, 32–42.
Drewnowski A (1999). Intense sweeteners and energy density of foods: implications for weight control. Eur J Clin Nutr 53, 757–763.
Drewnowski A (2003). The role of energy density. Lipids 38, 109–115.
Drewnowski A, Bellisle F (2007). Liquid calories, sugar, and body weight. Am J Clin Nutr (in press).
Drewnowski A, Krahn DD, Demitrack MA, Nairn K, Gosnell BA (1995). Naloxone, an opiate blocker, reduces the consumption of sweet high-fat foods in obese and lean female binge eaters. Am J Clin Nutr 61, 1206–1212.
Drewnowski A, Massien C, Louis-Sylvestre J, Fricker J, Chapelot D, Apfelbaum M (1994a). The effects of aspartame versus sucrose on motivational ratings, taste preferences, and energy intakes in obese and lean women. Int J Obes Relat Metab Disord 18, 570–578.
Drewnowski A, Massien C, Louis-Sylvestre J, Fricker J, Chapelot D, Apfelbaum M (1994b). Comparing the effects of aspartame and sucrose on motivational ratings, taste preferences, and energy intakes in humans. Am J Clin Nutr 59, 338–345.
Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ (2002). Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76, 911–922.
Epel E, Lapidus R, McEwen B, Brownell K (2001). Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology 26, 37–49.
Erlanson-Albertsson C (2005). How palatable food disrupts appetite regulation. Basic Clin Pharmacol Toxicol 97, 61–73.
European Parliament (2004). Authorized sweeteners, 2–3–2004. 8–26–2005.
European Parliament (1994). European Parliament and Council Directive, 94/35/EC. 6–30–1994. 8–26–2005.
Evans E (1989). Effect of withdrawal of artificial sweeteners on energy intake of stabilized post-obese women. Int J Obes Relat Metab Disord 13 (Suppl 1), 111.
Foltin RW, Fischman MW, Emurian CS, Rachlinski JJ (1988). Compensation for caloric dilution in humans given unrestricted access to food in a residential laboratory. Appetite 10, 13–24.
Foltin RW, Fischman MW, Moran TH, Rolls BJ, Kelly TH (1990). Caloric compensation for lunches varying in fat and carbohydrate content by humans in a residential laboratory. Am J Clin Nutr 52, 969–980.
Foltin RW, Rolls BJ, Moran TH, Kelly TH, McNelis AL, Fischman MW (1992). Caloric, but not macronutrient, compensation by humans for required-eating occasions with meals and snack varying in fat and carbohydrate. Am J Clin Nutr 55, 331–342.
Gatenby SJ, Aaron JI, Jack VA, Mela DJ (1997). Extended use of foods modified in fat and sugar content: nutritional implications in a free-living female population. Am J Clin Nutr 65, 1867–1873.
Gibson EL, Wardle J (2003). Energy density predicts preferences for fruit and vegetables in 4-year-old children. Appetite 41, 97–98.
Gross LS, Li L, Ford ES, Liu S (2004). Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr 79, 774–779.
Harnack L, Stang J, Story M (1999). Soft drink consumption among US children and adolescents: nutritional consequences. J Am Diet Assoc 99, 436–441.
Himaya A, Fantino M, Antoine JM, Brondel L, Louis-Sylvestre J (1997). Satiety power of dietary fat: a new appraisal. Am J Clin Nutr 65, 1410–1418.
Ireland-Ripert J, Favier JC, Tanneau X, Feinberg M (1997). Répertoire général des aliments. Tome 5 Aliments de marque. Paris: Lavoisier Tec & Doc, pp 197–198.
Isganaitis E, Lustig RH (2005). Fast food, central nervous system insulin resistance, and obesity. Arterioscler Thromb Vasc Biol 25, 2451–2462.
Johnson SL, McPhee L, Birch LL (1991). Conditioned preferences: young children prefer flavors associated with high dietary fat. Physiol Behav 50, 1245–1251.
Jordan HA (1969). Voluntary intragastric feeding: oral and gastric contributions to food intake and hunger in man. J Comp Physiol Psychol 68, 498–506.
Kanders BS, Lavin JH, owalchuk MB (1990). Do aspartame (AMP)-sweetened foods and beverages in the long term aid in long-term control of body weight. Am J Clin Nutr 51, 515.
Kanders BS, Lavin PT, Kowalchuk MB, Greenberg I, Blackburn GL (1988). An evaluation of the effect of aspartame on weight loss. Appetite 11 (Suppl 1), 73–84.
King NA, Appleton K, Rogers PJ, Blundell JE (1999). Effects of sweetness and energy in drinks on food intake following exercise. Physiol Behav 66, 375–379.
Kissileff HR, Gruss LP, Thornton J, Jordan HA (1984). The satiating efficiency of foods. Physiol Behav 32, 319–332.
Lavin JH, French SJ, Read NW (1997). The effect of sucrose- and aspartame-sweetened drinks on energy intake, hunger and food choice of female, moderately restrained eaters. Int J Obes Relat Metab Disord 21, 37–42.
Levine AS, Kotz CM, Gosnell BA (2003). Sugars and fats: the neurobiology of preference. J Nutr 133, 831S–834S.
Levitsky DA, Obarzanek E, Mrdjenovic G, Strupp BJ (2005). Imprecise control of energy intake: absence of a reduction in food intake following overfeeding in young adults. Physiol Behav 84, 669–675.
Louis-Sylvestre J (1987). Adaptation of food ingestion to energy expenditure]. Reprod Nutr Dev 27, 71–188.
Louis-Sylvestre J, Tournier A, Verger P, Chabert M, Delorme B, Hossenlopp J (1989). Learned caloric adjustment of human intake. Appetite 12, 95–103.
Lucas F, Bellisle F (1987). The measurement of food preferences in humans: do taste-and-spit tests predict consumption? Physiol Behav 39, 739–743.
Lustig RH (2001). The neuroendocrinology of childhood obesity. Pediatr Clin North Am 48, 909–930.
Maller O, Desor JA (1973). Effect of taste on ingestion by human newborns. Symp Oral Sens Percept 4, 279–291.
Mattes R (1990a). Effects of aspartame and sucrose on hunger and energy intake in humans. Physiol Behav 47, 1037–1044.
Mattes R (1990b). Hunger ratings are not a valid proxy measure of reported food intake in humans. Appetite 15, 103–113.
Mattes RD, Hollis J, Hayes D, Stunkard AJ (2005). Appetite: measurement and manipulation misgivings. J Am Diet Assoc 105 (5 Suppl 1), S87–S97.
Mattes RD, Pierce CB, Friedman MI (1988). Daily caloric intake of normal-weight adults: response to changes in dietary energy density of a luncheon meal. Am J Clin Nutr 48, 214–219.
Melanson KJ, Westerterp-Plantenga MS, Saris WH, Smith FJ, Campfield LA (1999a). Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat. Am J Physiol 277, R337–R345.
Melanson KJ, Westerterp-Plantenga MS, Saris WH, Smith FJ, Campfield LA (1999b). Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat. Am J Physiol 277, R337–R345.
Mintz S (1985). Sweetness and Power: The Place of Sugar in Modern History. Viking: New York.
Naismith D, Rhodes C (1995). Adjustment in energy intake following the covert removal of sugar from the diet. J Hum Nutr Diet 8, 167–175.
Ninomyia Y, Shigemura N, Yasumatsu K, Ohta R, Sugimoto K, Nakashima K et al. (2002). Leptin and sweet taste. Vitam Horm 64, 221–248.
Perez C, Dalix AM, Guy-Grand B, Bellisle F (1994). Human responses to five concentrations of sucrose in a dairy product: immediate and delayed palatability effects. Appetite 23, 165–178.
Porikos KP, Booth G, Van Itallie TB (1977). Effect of covert nutritive dilution on the spontaneous food intake of obese individuals: a pilot study. Am J Clin Nutr 30, 1638–1644.
Porikos KP, Hesser MF, Van Itallie TB (1982). Caloric regulation in normal-weight men maintained on a palatable diet of conventional foods. Physiol Behav 29, 293–300.
Prentice AM, Jebb SA (2003). Fast foods, energy density and obesity: a possible mechanistic link. Obes Rev 4, 187–194.
Raben A, Vasilaras TH, Moller AC, Astrup A (2002). Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr 76, 721–729.
Reid M, Hammersley R (1998). The effects of blind substitution of aspartame-sweetened for sugar-sweetened soft drinks on appetite and mood. Br Food J 100, 254–259.
Renwick AG (1994). Intense sweeteners, food intake, and the weight of a body of evidence. Physiol Behav 55, 139–143.
Rodin J (1975). Effects of obesity and set point on taste responsiveness and ingestion in humans. J Comp Physiol Psychol 89, 1003–1009.
Rodin J (1990). Comparative effects of fructose, aspartame, glucose, and water preloads on calorie and macronutrient intake. Am J Clin Nutr 51, 428–435.
Rogers PJ, Blundell JE (1989). Separating the actions of sweetness and calories: effects of saccharin and carbohydrates on hunger and food intake in human subjects. Physiol Behav 45, 1093–1099.
Rogers PJ, Blundell JE (1993). Intense sweeteners and appetite. Am J Clin Nutr 58, 120–122.
Rogers PJ, Carlyle JA, Hill AJ, Blundell JE (1988). Uncoupling sweet taste and calories: comparison of the effects of glucose and three intense sweeteners on hunger and food intake. Physiol Behav 43, 547–552.
Rolls BJ, Drewnowski A, Ledikwe JH (2005). Changing the energy density of the diet as a strategy for weight management. J Am Diet Assoc 105 (Suppl 1), S98–S103.
Rolls BJ, Kim S, Fedoroff IC (1990). Effects of drinks sweetened with sucrose or aspartame on hunger, thirst and food intake in men. Physiol Behav 48, 19–26.
Rolls BJ, Laster LJ, Summerfelt A (1989). Hunger and food intake following consumption of low-calorie foods. Appetite 13, 115–127.
Rolls BJ, Roe LS, Kral TV, Meengs JS, Wall DE (2004). Increasing the portion size of a packaged snack increases energy intake in men and women. Appetite 42, 63–69.
Saris WH (2003). Sugars, energy metabolism, and body weight control. Am J ClinNutr 78, 850S–857S.
Schiffman SS, Graham BG, Sattely-Miller EA, Peterson-Dancy M (2000). Elevated and sustained desire for sweet taste in african-americans: a potential factor in the development of obesity. Nutrition 16, 886–893.
Schwartz MW (2006). Central nervous system regulation of food intake. Obesity (Silver Spring) 14 (Suppl 1), 1S–8S.
Serra-Majem L, Ribas L, Ingles C, Fuentes M, Lloveras G, Salleras L (1996). Cyclamate consumption in Catalonia, Spain (1992): relationship with the body mass index. Food Addit Contam 13, 695–703.
Smeets PAM, de Graaf C, Stafleu A, van Osch MJP, van der Grand J (2005). Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories. Am J Clin Nutr 82, 1011–1016.
Stubbs J, Ferres S, Horgan G (2000). Energy density of foods: effects on energy intake. Crit Rev Food Sci Nutr 40, 481–515.
Tordoff MG, Alleva AM (1990a). Oral stimulation with aspartame increases hunger. Physiol Behav 47, 555–559.
Tordoff MG, Alleva AM (1990b). Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight. Am J Clin Nutr 51, 963–969.
Tsuchiya A, Almiron-Roig E, Lluch A, Guyonnet D, Drewnowski A (2006). Higher satiety ratings following yogurt consumption relative to fruit drink or dairy fruit drink. J Am Diet Assoc 106, 550–557.
US Department of Health (1977). Taste and Development, The Genesis of Sweet Preference. Publication No. (NIH) 77–1068. DHEW: Bethesda.
Van Wymelbeke V, Beridot-Therond ME, de LaGuéronnière V, Fantino M (2004). Influence of repeated consumption of beverages containing sucrose or intense sweeteners on food intake. Eur J ClinNutr 58, 154–161.
Volatier JL, Verger P (1999). Recent national French food and nutrient intake data. Br J Nutr 81 (Suppl 2), S57–S59.
Walike BC, Jordan HA, Stellar E (1969). Preloading and the regulation of food intake in man. J Comp Physiol Psychol 68, 327–333.
Wilson JF (2000). Lunch eating behavior of preschool children. Effects of age, gender, and type of beverage served. Physiol Behav 70, 27–33.
Yeomans MR (1996). Palatability and the micro-structure of feeding in humans: the appetizer effect. Appetite 27, 119–133.
Yeomans MR, Lee MD, Gray RW, French SJ (2001). Effects of test-meal palatability on compensatory eating following disguised fat and carbohydrate preloads. Int J Obes Relat Metab Disord 25, 1215–1224.
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Bellisle, F., Drewnowski, A. Intense sweeteners, energy intake and the control of body weight. Eur J Clin Nutr 61, 691–700 (2007). https://doi.org/10.1038/sj.ejcn.1602649
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