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Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients



Alpha-linolenic acid (ALA) is the natural precursor of the cardioprotective long-chain n−3 fatty acids. Available data indicate a possible beneficial effect of ALA on cardiovascular disease (CVD), but the response of various CVD risk factors to increased ALA intake is not well characterized. The purpose of the present study was to examine the effect of increased ALA intake on blood pressure in man.

Design, setting, subjects and interventions:

We used a prospective, two-group, parallel-arm design to examine the effect of a 12-week dietary supplementation with flaxseed oil, rich in ALA (8 g/day), on blood pressure in middle-aged dyslipidaemic men (n=59). The diet of the control group was supplemented with safflower oil, containing the equivalent n−6 fatty acid (11 g/day linoleic acid (LA); n=28). Arterial blood pressure was measured at the beginning and at the end of the dietary intervention period.


Supplementation with ALA resulted in significantly lower systolic and diastolic blood pressure levels compared with LA (P=0.016 and P=0.011, respectively, from analysis of variance (ANOVA) for repeated measures).


We observed a hypotensive effect of ALA, which may constitute another mechanism accounting in part for the apparent cardioprotective effect of this n−3 fatty acid.


Greek Ministry of Development, General Secretariat for Research and Technology.

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  • Adam O (1989). Effects of linoleic and alpha linolenic acids intake on blood pressure in man. Prog Clin Biol Res 301, 523–528.

    Google Scholar 

  • Adam O, Wolfram G, Zollner N (1986). Effect of alpha-linolenic acid in the human diet on linoleic acid metabolism and prostaglandin biosynthesis. J Lipid Res 27, 421–426.

    CAS  PubMed  Google Scholar 

  • Beilin LJ (1987). Diet and hypertension: critical concepts and controversies. J Hypertens 5 (Suppl), S447–S457.

    CAS  Google Scholar 

  • Bemelmans WJ, Broer J, Feskens EJ, Smit AJ, Muskiet FA, Lefrandt JD et al. (2002). Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study. Am J Clin Nutr 75, 221–227.

    Article  CAS  Google Scholar 

  • Bemelmans WJ, Muskiet FA, Feskens EJ, de Vries JH, Broer J, May JF et al. (2000). Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease. Eur J Clin Nutr 54, 865–871.

    Article  CAS  Google Scholar 

  • Berry EM, Hirsch J (1986). Does dietary linolenic acid influence blood pressure? Am J Clin Nutr 44, 336–340.

    Article  CAS  Google Scholar 

  • Burdge G (2004). Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care 7, 137–144.

    Article  CAS  Google Scholar 

  • Burdge GC, Calder PC (2005). Alpha-linolenic acid metabolism in adult humans: the effects of gender and age on conversion to longer-chain polyunsaturated fatty acids. Eur J Lipid Sci Tech 107, 426–439.

    Article  CAS  Google Scholar 

  • Codde JP, Beilin LJ (1986). Prostaglandins and experimental hypertension: a review with special emphasis on the effect of dietary lipids. J Hypertens 4, 675–686.

    Article  CAS  Google Scholar 

  • Djousse L, Arnett DK, Pankow JS, Hopkins PN, Province MA, Ellison RC (2005). Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study. Hypertension 45, 368–373.

    Article  CAS  Google Scholar 

  • Djousse L, Folsom AR, Province MA, Hunt SC, Ellison RC (2003). Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr 77, 819–825.

    Article  CAS  Google Scholar 

  • Djousse L, Pankow JS, Eckfeldt JH, Folsom AR, Hopkins PN, Province MA et al. (2001). Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr 74, 612–619.

    Article  CAS  Google Scholar 

  • Finnegan YE, Howarth D, Minihane AM, Kew S, Miller GJ, Calder PC et al. (2003a). Plant and marine derived (n−3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. J Nutr 133, 2210–2213.

    Article  CAS  Google Scholar 

  • Finnegan YE, Minihane AM, Leigh-Firbank EC, Kew S, Meijer GW, Muggli R et al. (2003b). Plant- and marine-derived n−3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 77, 783–795.

    Article  CAS  Google Scholar 

  • Galli C, Agradi E, Petroni A, Tremoli E (1980). Dietary essential fatty acids, tissue fatty acids and prostaglandin synthesis. Prog Food Nutr Sci 4, 1–7.

    CAS  PubMed  Google Scholar 

  • Grimsgaard S, Bonaa KH, Jacobsen BK, Bjerve KS (1999). Plasma saturated and linoleic fatty acids are independently associated with blood pressure. Hypertension 34, 478–483.

    Article  CAS  Google Scholar 

  • Harper CR, Edwards MJ, Defilipis AP, Jacobson TA (2006). Flaxseed oil increases the plasma concentrations of cardioprotective (n−3) fatty acids in humans. J Nutr 136, 83–87.

    Article  CAS  Google Scholar 

  • Harper CR, Jacobson TA (2005). Usefulness of omega-3 fatty acids and the prevention of coronary heart disease. Am J Cardiol 96, 1521–1529.

    Article  CAS  Google Scholar 

  • Harris WS (2005). Alpha-linolenic acid: a gift from the land? Circulation 111, 2872–2874.

    Article  Google Scholar 

  • He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR et al. (2004). Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 109, 2705–2711.

    Article  Google Scholar 

  • Holub DJ, Holub BJ (2004). Omega-3 fatty acids from fish oils and cardiovascular disease. Mol Cell Biochem 263, 217–225.

    Article  CAS  Google Scholar 

  • Kestin M, Clifton P, Belling GB, Nestel PJ (1990). 3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n−3 and n−6 fatty acids from plants. Am J Clin Nutr 51, 1028–1034.

    Article  CAS  Google Scholar 

  • Knapp HR (1989). Omega-3 fatty acids, endogenous prostaglandins, and blood pressure regulation in humans. Nutr Rev 47, 301–313.

    Article  CAS  Google Scholar 

  • Mantzioris E, Cleland LG, Gibson RA, Neumann MA, Demasi M, James MJ (2000). Biochemical effects of a diet containing foods enriched with n−3 fatty acids. Am J Clin Nutr 72, 42–48.

    Article  CAS  Google Scholar 

  • Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G et al. (2006). Effects of dietary saturated, monounsaturated, and n−3 fatty acids on blood pressure in healthy subjects. Am J Clin Nutr 83, 221–226.

    Article  CAS  Google Scholar 

  • Riemersma RA, Wood DA, Butler S, Elton RA, Oliver M, Salo M et al. (1986). Linoleic acid content in adipose tissue and coronary heart disease. Br Med J 292, 1423–1427.

    Article  CAS  Google Scholar 

  • Salonen JT, Salonen R, Ihanainen M, Parviainen M, Seppanen R, Kantola M et al. (1988). Blood pressure, dietary fats, and antioxidants. Am J Clin Nutr 48, 1226–1232.

    Article  CAS  Google Scholar 

  • Salonen JT, Salonen R, Ihanainen M, Parviainen M, Seppanen R, Seppanen K et al. (1987). Vitamin C deficiency and low linolenate intake associated with elevated blood pressure: the Kuopio Ischaemic Heart Disease Risk Factor Study. J Hypertens 5 (Suppl), S521–S524.

    CAS  Google Scholar 

  • Simon JA, Fong J, Bernert Jr JT (1996). Serum fatty acids and blood pressure. Hypertension 27, 303–307.

    Article  CAS  Google Scholar 

  • Singer P, Berger I, Wirth M, Godicke W, Jaeger W, Voigt S (1986). Slow desaturation and elongation of linoleic and alpha-linolenic acids as a rationale of eicosapentaenoic acid-rich diet to lower blood pressure and serum lipids in normal, hypertensive and hyperlipemic subjects. Prostaglandins Leukot Med 24, 173–193.

    Article  CAS  Google Scholar 

  • Singer P, Jaeger W, Berger I, Barleben H, Wirth M, Richter-Heinrich E et al. (1990). Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. J Hum Hypertens 4, 227–233.

    CAS  PubMed  Google Scholar 

  • Wendland E, Farmer A, Glasziou P, Neil A (2006). Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review. Heart 92, 166–169.

    Article  CAS  Google Scholar 

  • Wilkinson P, Leach C, Ah-Sing EE, Hussain N, Miller GJ, Millward DJ et al. (2005). Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis 181, 115–124.

    Article  CAS  Google Scholar 

  • Williams CM, Burdge G (2006). Long-chain n−3 PUFA: plant v. marine sources. Proc Nutr Soc 65, 42–50.

    Article  CAS  Google Scholar 

  • Zollner N, Adam O, Wolfram G (1979). The influence of linoleic acid intake on the excretion of urinary prostaglandin metabolites. Res Exp Med (Berlin) 175, 149–153.

    Article  CAS  Google Scholar 

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We thank Dr E Karpodini, Dr E Theriou and the staff of the Department of Cardiology, Laiko Hospital, for assistance with subject management. This project was supported by the Greek Ministry of Development, General Secretariat for Research and Technology (grant no. 97EL-55).

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Correspondence to A Zampelas.

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Guarantor: A Zampelas.

Contributors: GKP, VK, and AZ were involved in all aspects of the study, including design, data collection, analysis and interpretation, and writing and editing the manuscript; FM and DBP participated in analysing and interpreting the data, and in writing and editing the manuscript.

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Paschos, G., Magkos, F., Panagiotakos, D. et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 61, 1201–1206 (2007).

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  • omega-3
  • vegetable oil
  • hypertension

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