Synthesis of the Antibiotic, Penicillic Acid


Penicillic acid, first isolated by Alsberg and Black1 from Penicillium puberulum Bainier and later by Birkinshaw, Oxford and Raistrick2 from Penicillium cyclopium Westling, was shown to possess the structure (IV) by the latter authors. Later it was observed that the compound was a powerful antibacterial agent, and Oxford3 has determined that it is much more active than penicillin against Gramnegative organisms.

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  1. U.S. Dept. Agric. Bureau Plant Ind. Bull., Nos. 119, 270.

  2. Biochem. J., 30, 394 (1936).

  3. Chem. and Ind., 61, 48 (1942).

  4. Raphael, J. Chem. Soc., in the press.

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RAPHAEL, R. Synthesis of the Antibiotic, Penicillic Acid. Nature 160, 261–262 (1947).

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