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Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients



To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone.


Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin.


General Clinical Research Center at Vanderbilt University Medical Center.


Five chronic hemodialysis (CHD) patients.


Intra-dialytic parenteral nutrition (IDPN) with or without exercise.


Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2±3.1% per day versus 17.7±1.9% per day, P<0.05).


Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients.

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The present work is partly supported by the National Institutes of Health Grants R01-DK45604, K24-DK62849 and DK-20593 from the National Institute of Diabetes, Digestive and Kidney Diseases, M01 RR-00095 from the National Center for Research Resources and Satellite Health Norman Coplon Extramural Grant Program. The excellent technical assistance of D Levenhagen, S Vaughan, J Harvell, M Zheng, P Egbert, F Moustofi and the nursing staff on the GCRC is appreciated. LB Pupim is an employee of Amgen Inc since August of 2005.

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Correspondence to T A Ikizler.

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Pupim, L., Flakoll, P. & Ikizler, T. Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients. Eur J Clin Nutr 61, 686–689 (2007).

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  • albumin
  • catabolism
  • hemodialysis
  • synthesis
  • exercise

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