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  • Original Article
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Effect of a novel dietary supplement on skin aging in post-menopausal women

European Journal of Clinical Nutrition volume 60, pages 1201–1206 (2006)Cite this article

Abstract

Objective:

The aim of the present study was to quantify the effects on skin in post-menopausal women of a novel dietary supplement (Imedeen Prime Renewal™) that contained soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract.

Design:

The study was a 6-month double blind, placebo controlled, randomized study on healthy post-menopausal females.

Setting:

The study was performed at a commercial Contract Research Organisation (TJ Stephens & Associates Inc., TX, USA).

Interventions:

Two tablets of Imedeen Prime Renewal™ or placebo were given twice daily for 6 months.

Subjects:

Thirty-eight (active group) and 42 (placebo group) subjects completed the study out of 100.

Results:

Clinical grading showed that the active group had a significantly greater improvement (P<0.05) compared to placebo for the face after 6 months treatment for: forehead, periocular and perioral wrinkles, mottled pigmentation, laxity, sagging, under eye dark circles and overall apperance; skin on the décolletage after 2, 3 and 6 months treatment and skin on the hand after 3 and 6 months treatment. Photo evaluation showed that the active group had a significantly greater improvement (P<0.05) on the face after 3 and 6 months for several parameters. Ultrasound measurements showed that the active group had a significantly greater improvement (P<0.0001) for density measurements after 6 months treatment.

Conclusion:

In summary, this novel dietary supplement, Imedeen Prime Renewal™, provides improved condition, structure and firmness of the skin in post-menopausal women after 6 months.

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Acknowledgements

Ferrosan A/S manufactured Imedeen Prime Renewal™ and sponsored the study. TJ Stephens & Associates Inc. conducted the study and analysed the data and the manuscript was written by GR Lange Skovgaard and AS Jensen.

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Authors and Affiliations

  1. Department of Dermatology, University of Copenhagen, Copenhagen, Denmark

    G R Lange Skovgaard

  2. Ferrosan A/S, Soeborg, Denmark

    A S Jensen

  3. Stephens & Associates Inc, Carrollton, TX, USA

    M L Sigler

Authors
  1. G R Lange Skovgaard
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  2. A S Jensen
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  3. M L Sigler
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Corresponding author

Correspondence to A S Jensen.

Additional information

Guarantor: AS Jensen.

Contributors: GRLS and ASJ wrote the manuscript. MLS conducted the study and analysed the data.

Sources of support: Ferrosan A/S, Denmark.

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Skovgaard, G., Jensen, A. & Sigler, M. Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr 60, 1201–1206 (2006). https://doi.org/10.1038/sj.ejcn.1602438

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602438

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