Table 2 Clinical grading values of face, hand and décolletage in post-menopausal women before and after supplementation with dietary supplement or placebo for 2, 3 and 6 months

From: Effect of a novel dietary supplement on skin aging in post-menopausal women

  Active group (n=38) Placebo group (n=42)
  Baseline Month 2 Month 3 Month 6 Baseline Month 2 Month 3 Month 6 ANOVA P-value a
Face
 Forehead wrinkles 4.4±0.3b 4.3±0.3 4.1±0.3 4.0±0.3 4.7±0.4 4.6±0.4 4.5±0.3 4.6±0.3 0.01c
 Periocular wrinkles 5.4±0.2 5.0±0.2 4.7±0.2 4.6±0.2 5.4±0.2 5.1±0.2 4.8±0.2 4.9±0.2 0.02c
 Perioral fine wrinkles 5.1±0.3 5.0±0.3 4.7±0.3 4.5±0.3 5.2±0.3 5.1±0.2 4.9±0.3 4.9±0.3 0.01c
 Mottled hyper pigmentation 4.6±0.2 4.4±0.2 4.1±0.2 3.9±0.2 4.8±0.2 4.6±0.2 4.4±0.2 4.4±0.2 <0.01c
 Tactile roughness 2.2±0.2 1.2±0.2 0.7±0.1 0.5±0.1 2.8±0.2 1.7±0.2 1.1±0.2 1.1±0.2 NS
 Laxity 4.9±0.2 4.8±0.2 4.2±0.2 4.0±0.2 4.8±0.2 4.7±0.2 4.3±0.2 4.2±0.2 0.01c
 Sagging 4.8±0.2 4.7±0.2 4.4±0.2 4.2±0.2 4.9±0.2 4.9±0.2 4.6±0.2 4.6±0.2 0.01c
 Teleangiectasia 2.7±0.3 2.6±0.3 2.4±0.3 2.3±0.2 3.6±0.3 3.6±0.3 3.4±0.3 3.4±0.3 NS
 Under eye dark circles 2.6±0.2 2.4±0.2 2.1±0.2 2.1±0.2 2.5±0.2 2.4±0.2 2.3±0.2 2.3±0.2 0.01c
 Overall facial appearance 5.3±0.2 5.1±0.2 4.8±0.2 4.5±0.2 5.5±0.2 5.2±0.2 5.0±0.2 5.1±0.2 <0.01c
Decollétage
 Crepyness 3.7±0.2 3.6±0.2d 3.4±0.2d 3.4±0.2 3.7±0.1 3.7±0.2 3.7±0.2 3.7±0.2 <0.01c
 Mottled hyper pigmentation 5.0±0.2 4.9±0.2 4.6±0.2 4.6±0.2 5.1±0.2 5.0±0.2 4.8±0.2 4.9±0.2 NS
 Overall appearance 5.0±0.2 4.9±0.2 4.6±0.2d 4.5±0.2 5.0±0.2 5.0±0.2 4.9±0.2 5.0±0.2 <0.01c
Hand
 Crepyness 4.9±0.2 4.6±0.3 4.1±0.3d 4.0±0.3 5.4±0.3 5.2±0.3 4.9±0.3 4.9±0.3 <0.01c
 Thinnness 4.4±0.3 4.2±0.3 3.9±0.3 3.8±0.3 4.6±0.4 4.5±0.3 4.3±0.3 4.3±0.3 NS
 Mottled hyper pigmentation 4.7±0.2 4.0±0.3 3.4±0.3d 3.3±0.3 4.9±0.3 4.4±0.3 4.0±0.3 3.9±0.3 NS
 Pinch recoil 2.6±0.1 2.4±0.1 2.3±0.1 2.1±0.1 2.8±0.1 2.6±0.1 2.3±0.1 2.4±0.1 NS
  1. aDifference in change between groups, Student's t-test (unpaired t-test).
  2. bMean values±s.e.m.
  3. cSignificant difference between active group and placebo at month 6.
  4. dSignificant difference between active group and placebo (P<0.05).