Table 3 Changes in serum folate, red blood cell (RBC) folate, serum vitamin B-12, total vitamin B-2, and plasma total homocysteine (tHcy) concentrations during the interventiona

From: Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects

  Control group (n=8) FA group (n=9) R group (n=7) FAR group (n=8)
Serum folate (nmol/l)
 Baseline 13.1±5.2 10.7±3.4 11.8±3.6 14.1±7.9
 2-wk 12.8±3.2 28.8±4.3b 11.3±4.3 27.5±9.0b
Δc −0.7±1.6 18.0±1.5d,e 0.3±1.7 14.3±1.6d,e
RBC folate (nmol/l)
 Baseline 407±68 386±63 361±75 398±45
 2-wk 403±72 525±47b 424±58 488±56b
Δ −4±26 56±12d,e 23±11 48±21d,e
Vitamin B-12 (nmol/l)
 Baseline 731±355 645±420 562±243 525±267
 2-wk 602±208 613±383 450±377 439±232
Δ −124±84 −21±78 −40±88 −53±16
Vitamin B-2 (mmol/l)
 Baseline 3.8±0.5 3.6±0.6 3.6±0.5 4.2±0.8
 2-wk 3.9±0.4 3.8±0.8 4.0±0.6 4.1±1.0
Δ 0.1±0.2 0.2±1.5 0.3±1.2 0.0±0.2
tHcy (μmol/l)
 Baseline 5.7±3.0 7.4±3.0 8.2±3.9f 7.4±4.0
 2-wk 5.9±2.6 6.5±2.9c 8.0±3.6 7.0±3.5
Δ 0.0±0.4 −0.9±0.4 0.1±0.5 −0.4±1.6
  1. aMean±s.d.
  2. bSignificantly different from baseline based on Wilcoxon's signed rank test.
  3. cMean change value in within-group during the study, adjusted for baseline BMI, plasma tHcy concentration and each run-in data.
  4. dSignificantly different from control group based on ANCOVA.
  5. eSignificantly different from riboflavin group based on ANCOVA.
  6. fSignificantly different fromcontrol group based on Mann–Whitney U test.