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Effects of probiotics on the severity of experimental acute pancreatitis

Abstract

Objective:

This study was designed to evaluate the effects of probiotics on the severity of experimental acute pancreatitis.

Design:

Experimental study.

Setting:

Experiments were done in a laboratory at Haydarpasa Numune Teaching and Research Hospital.

Subjects:

A total of 50 Wistar rats were randomly divided into five groups.

Interventions:

Group 1 was control group. Group 2 received an intraperitoneal injection of a 20% solution in 0.15 mol/l NaCL. Group 3 was injected NaCL and fed with probiotics. Acute pancreatitis was induced in rats by intrperitoneal injection of L-Arginine in groups 4 and 5. The rats in group 5 were treated with probiotics. The pancreas was removed for histologic examination. Evaluation of the pathologic changes was done by a new combined histopathologic grading scale.

Results:

The mean scores of fibrosis, acinar cell loss, oedema, parenchymal necrosis, mononuclear cells infiltration, polymorphonuclear leucocytes infiltration, ductal damage and atypical reactive regeneration in group 5 were significantly lower than group 4.

Conclusions:

We demonstrated that enteral feedings with added probiotics can reduce the severity of acute pancreatitis.

Sponsorship:

None.

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Correspondence to M A T Muftuoglu.

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Muftuoglu, M., Isikgor, S., Tosun, S. et al. Effects of probiotics on the severity of experimental acute pancreatitis. Eur J Clin Nutr 60, 464–468 (2006). https://doi.org/10.1038/sj.ejcn.1602338

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602338

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