Abstract
Objective:
The objective of this study was to assess vitamin D status during late-summer and late-winter/early-spring in postmenopausal Irish women, and whether it was influenced by vitamin D-containing supplement use.
Design:
A longitudinal observational study.
Setting:
Cork City, Ireland (51° north).
Subjects:
A total of 59 apparently healthy, free-living, postmenopausal women aged between 51 and 69 y were sampled during February/March 2002. Of these, 48 and 47 returned during August/September 2002 and February/March 2003, respectively. None of the women were suffering from any medical condition likely to affect vitamin D status. Fasting serums were collected and analysed for 25-hydroxyvitamin D (25 (OH) D) and parathyroid hormone (PTH) by enzyme immunoassays.
Results:
Mean daily intake of vitamin D was 3.2 μg from food sources alone and 5.8 μg when vitamin D-containing supplements were included (P<0.01). Serum 25 (OH) D was significantly lower (P<0.001) during February/March 2002 than both August/September 2002 and February/March 2003. Serum 25 (OH) D was also significantly higher (P≤0.05) in women who were vitamin D-containing supplement users than nonusers during all three sampling points. Between 17 and 36% of women had inadequate vitamin D status (defined as serum 25 (OH) D <40 nmol/l) during late-winter, but only 4% had inadequate vitamin D status during late-summer. Serum 25 (OH) D was inversely related to serum PTH (r=−0.33; P=0.028).
Conclusion:
Suboptimal vitamin D status is common in postmenopausal Irish women during winter. Vitamin D supplementation is associated with improved vitamin D status, even during summertime.
Sponsorship:
Irish Government under the National Development Plan 2000–2006.
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References
Chapuy MC & Meunier PJ (1997): Vitamin D insufficiency in adults and the elderly. In Vitamin D, eds, D Feldman, F Glorieux & JW Pike, pp 679–693. San Diego, CA: Academic press.
Chapuy MC, Chapuy P & Meunier PJ (1987): Calcium and vitamin D supplements: effects on calcium metabolism in elderly people. Am. J. Clin. Nutr. 46, 324–328.
Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S & Meunier PJ (1997): Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos. Int. 7, 439–443.
Compston JE (1998): Vitamin D deficiency: time for action. BMJ 317, 1466–1467.
Dawson-Hughes B, Harris SS, Krall EA & Dallal GE (1997a): Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age and older. N. Engl. J. Med. 337, 670–676.
Dawson-Hughes B, Harris SS & Dallal GE (1997b): Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women. Am. J. Clin. Nutr. 65, 67–71.
Food and Agriculture Organization/World Health Organization (1998): Human vitamin and mineral requirements: a report of the joint Food and Agriculture Organization/World Health Organization expert consultation, Bangkok, Thailand. Food and Nutrition Division, Rome http://ftp.fao.org/es/esn/nutrition.
Food Safety Authority of Ireland (1999): Recommended Dietary Allowances for Ireland. Dublin: Government Publications Sales Office.
Freaney R, McBrinn Y & McKenna MJ (1993): Secondary hyperparathyroidism in elderly people: combined effect of renal insufficiency and vitamin D deficiency. Am. J. Clin. Nutr. 58, 187–191.
Heaney RP & Weaver CM (2003): Calcium and vitamin D. Endocrinol. Metab. Clin. N. Am. 32, 181–194.
Henderson L, Irving K, Gregory J, Bates CJ, Prentice A, Perks J, Swan G & Farron M (2003): The National Diet and Nutrition Survey: adults aged 19 to 64 years—vitamin and mineral intake and urinary analytes. http://www.foodstandards.gov.uk/multimedia/pdfs/ndnsv3.pdf.
Hill TR, O’Brien MM, Kiely M, Flynn A & Cashman KD (2004): Vitamin D intakes in 18–64 year-old Irish adults. Eur. J. Clin. Nutr. 58, 1509–1517.
Holick MF (2004): Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease and osteoporosis. Am. J. Clin. Nutr. 79, 362–371.
Institute of Medicine (1997): Dietary Reference Intakes. For Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: Food and Nutrition Board, National Academy Press.
Karkkainen MU, Wiersma JW & Lamberg-Allardt CJ (1997): Postprandial parathyroid response to four calcium-rich foodstuffs. Am. J. Clin. Nutr. 65, 1726–1730.
Kiely M, Flynn A, Harrington KE, Robson PJ, O’Connor N, Hannon EM, O’Brien MM, Bell S & Strain JJ (2001): The efficacy and safety of nutritional supplement use in a representative sample of adults in the North/South Ireland Food Consumption Survey. Public Health Nutr. 4, 1089–1097.
Lips P (2001): Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr. Rev. 22, 477–501.
Lips P (2004): Which circulating level of 25-hydroxyvitamin D is appropriate? J. Steroid Biochem. Mol. Biol. 89–90, 611–614.
Lips P, Netelenbos JC, Jongen MJM, van Ginkel FC, Althuis AL, van Schaik CL, van der Vijgh WJF, Vermeiden JPW & van der Meer C (1982): Histomorphometric profile and vitamin D status in patients with femoral neck fracture. Metab. Bone Dis. Relat. Res. 4, 85–93.
Lips P, van Ginkel FC, Jongen MJ, Rubertus F, van der Vijgh WJ & Netelenbos JC (1987): Determinants of vitamin D status in patients with hip fracture and in elderly control subjects. Am. J. Clin. Nutr. 46, 1005–1010.
Lips P, Duong T, Oleksik A, Black D, Cummings S, Cox D & Nickelsen T (2001): A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J. Clin. Endocrinol. Metab. 3, 1212–1221.
McKenna MJ (1992): Differences in vitamin D status between countries in young adults and the elderly. Am. J. Clin. Nutr. 93, 69–77.
McKenna MJ & Freaney R (1998): Secondary hyperparathyroidism in the elderly: means to defining hypovitaminosis D. Osteoporos. Int. 8, S3–S6.
McKenna MJ, Freaney R, Keating D & Muldowney FP (1981): The prevalence and management of vitamin D deficiency in an acute geriatric unit. Ir. Med. J. 74, 336–338.
McKenna MJ, Freaney R, Meade A & Muldowney FP (1985): Hypovitaminosis D and elevated serum alkaline phosphatase in elderly Irish people. Am. J. Clin. Nutr. 41, 101–109.
Meade A, Moloney M & O’Keeffe D (1986): Prevalence of vitamin D deficiency in the elderly in two rural areas in Ireland. Ir. Med. J. 79, 359.
Ministry of Agriculture, Fisheries and Food (MAFF) (1997): Food Portion Sizes. London: The Stationary Office.
Miyamoto K, Ito M, Segawa H & Kuwahata M (2000): Secondary hyperparathyroidism and phosphate sensing in parathyroid glands. J. Med. Invest. 47, 118–122.
Ooms ME, Lips P, Roos JC, van der Vijgh WJ, Popp-Snijders C, Bezemer PD & Bouter LM (1995): Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. J. Bone Miner. Res. 10, 1177–1184.
Ovesen L, Andersen R & Jakobsen J (2003): Geographical differences in vitamin D status, with particular reference to European countries. Proc. Nutr. Soc. 62, 813–821.
Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R & Whedon GD (1982): Vitamin D and bone health in the elderly. Am. J. Clin. Nutr. 36, 1014–1031.
Rapuri PB, Kinyamu HK, Gallagher JC & Haynatzka V (2002): Seasonal changes in calciotropic hormones, bone markers, and bone mineral density in elderly women. J. Clin. Endocrinol. Metab. 87, 2024–2032.
Rasmussen LB, Hansen GL, Hansen E, Koch B, Mosekilde L, Mølgaard C, Sørensen OH & Ovesen L (2000): Vitamin D: should the supply in the Danish population be increased? Int. J. Food Sci. Nutr. 51, 209–215.
Snedecor GW & Cochran WG (1967): Statistical Methods. Ames, IA: Iowa State University Press.
Stamp TCB & Round JM (1974): Seasonal changes in human plasma levels of 25 (OH) vitamin D. Nature 247, 563–565.
Van Der Wielen RPJ, Lowik MRH, Van Den Berg H, De Groot LCPGM, Haller J, Moreiras O & Van Staveren WA (1995): Serum vitamin D concentrations among elderly people in Europe. Lancet 346, 207–210.
Van Leeuwen JPTM, Van Den Bemd G-JCM, Van Driel M, Buurman CJ & Pols AP (2001): 24,25-Dihydroxyvitamin D3 and bone metabolism. Steroids 66, 375–380.
Vieth R (1999): Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am. J. Clin. Nutr. 69, 842–856.
Webb AR, Kline LW & Holick MF (1988): Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J. Clin. Endocrinol. Metab. 67, 373–378.
Zittermann A (2003): Vitamin D in preventive medicine: are we ignoring the evidence? Br. J. Nutr. 89, 552–572.
Acknowledgements
This work was supported by funding made available by the Irish Government under the National Development Plan 2000–2006.
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Guarantor: KD Cashman.
Contributors: TH contributed to design, execution, analysis and writing of the study. AC contributed to dietary assessment and analysis. MOB and AF contributed to design, execution and analysis of the study. MK contributed to design and writing of the study. KDC contributed to design, analysis and writing of the study.
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Hill, T., Collins, A., O'Brien, M. et al. Vitamin D intake and status in Irish postmenopausal women. Eur J Clin Nutr 59, 404–410 (2005). https://doi.org/10.1038/sj.ejcn.1602088
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DOI: https://doi.org/10.1038/sj.ejcn.1602088
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