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Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study

European Journal of Clinical Nutrition volume 59, pages 456–458 (2005)Cite this article

Abstract

Objective:

To assess the effects of soybean-derived pinitol on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus.

Design:

Randomized, double-blind, placebo-controlled, parallel-group trial.

Setting:

Pusan Paik Hospital, Pusan, Republic of Korea.

Interventions:

A total of 30 patients with type II diabetes received an oral dose of 600 mg soybean-derived pinitol or placebo twice daily for 13 weeks.

Results:

Pinitol significantly decreased mean fasting plasma glucose, insulin, fructosamine, HbA1c, and the homeostatic model assessment insulin resistance index (HOMA-IR, P<0.001). Pinitol significantly decreased total cholesterol, LDL-cholesterol, the LDL/HDL-cholesterol ratio, and systolic and diastolic blood pressure and increased HDL-cholesterol (P<0.05).

Conclusions:

These data suggest that soybean-derived pinitol may be beneficial in reducing cardiovascular risk in Korean type II diabetes.

Sponsorship:

This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (HMP 02-PJ1-PG3-22005-0011).

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Acknowledgements

We are grateful to Amicogen, Inc. (Jinju, Korea), for providing the soybean-derived pinitol.

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Authors and Affiliations

  1. Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Institute of Basic Sciences, Inje University, Gimhae, Republic of Korea

    J -I Kim & M -J Kang

  2. School of Food and Life Science, Institute for Food Sciences, Institute for Basic Sciences, Inje University, Gimhae, Republic of Korea

    J C Kim

  3. School of Food and Life Science, Institute for Food Sciences, Inje University, Gimhae, Republic of Korea

    M -S Lee

  4. Department of Microbiology, College of Agriculture, Gyeongsang National University, Jinju, Republic of Korea

    J -J Kim

  5. Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, Pusan, Republic of Korea

    I -J Cha

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  1. J -I Kim
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  2. J C Kim
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  3. M -J Kang
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  4. M -S Lee
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Corresponding author

Correspondence to J C Kim.

Additional information

Guarantor: J-I Kim.

Contributors: JCK was involved in study design. J-IK contributed to the practical organization of the trial. M-JK and M-SL were responsible for biochemical analyses. J-JK was responsible for design and statistical analyses. I-JC was responsible for project management. JCK and J-IK wrote the first draft of the paper and all authors contributed to the final draft.

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Kim, JI., Kim, J., Kang, MJ. et al. Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study. Eur J Clin Nutr 59, 456–458 (2005). https://doi.org/10.1038/sj.ejcn.1602081

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