Abstract
Objective:
To assess the effects of soybean-derived pinitol on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus.
Design:
Randomized, double-blind, placebo-controlled, parallel-group trial.
Setting:
Pusan Paik Hospital, Pusan, Republic of Korea.
Interventions:
A total of 30 patients with type II diabetes received an oral dose of 600 mg soybean-derived pinitol or placebo twice daily for 13 weeks.
Results:
Pinitol significantly decreased mean fasting plasma glucose, insulin, fructosamine, HbA1c, and the homeostatic model assessment insulin resistance index (HOMA-IR, P<0.001). Pinitol significantly decreased total cholesterol, LDL-cholesterol, the LDL/HDL-cholesterol ratio, and systolic and diastolic blood pressure and increased HDL-cholesterol (P<0.05).
Conclusions:
These data suggest that soybean-derived pinitol may be beneficial in reducing cardiovascular risk in Korean type II diabetes.
Sponsorship:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (HMP 02-PJ1-PG3-22005-0011).
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Acknowledgements
We are grateful to Amicogen, Inc. (Jinju, Korea), for providing the soybean-derived pinitol.
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Guarantor: J-I Kim.
Contributors: JCK was involved in study design. J-IK contributed to the practical organization of the trial. M-JK and M-SL were responsible for biochemical analyses. J-JK was responsible for design and statistical analyses. I-JC was responsible for project management. JCK and J-IK wrote the first draft of the paper and all authors contributed to the final draft.
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Kim, JI., Kim, J., Kang, MJ. et al. Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study. Eur J Clin Nutr 59, 456–458 (2005). https://doi.org/10.1038/sj.ejcn.1602081
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DOI: https://doi.org/10.1038/sj.ejcn.1602081
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