Objectives: Pizza eating has been favourably related to the risk of cardiovascular disease, but the data are limited. To evaluate the potential role of pizza consumption on the risk of acute myocardial infarction (AMI), we considered data from an Italian study.
Design: We conducted a hospital-based case–control study on 507 cases of nonfatal AMI and 478 controls in Milan, Italy, between 1995 and 1999.
Results: The multivariate odds ratios were 0.78 for occasional, 0.62 for regular and 0.44 for frequent eaters. The estimates were similar across strata of age, sex, smoking and other major covariates.
Conclusions: Some of the ingredients of pizza have been shown to have a favourable influence on the risk of cardiovascular disease. However, there is no single explanation for the present findings. Pizza may in fact represent a general indicator of Italian diet, that has been shown to have potential cardiovascular benefits.
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Bertuzzi M, Tavani A, Negri E & La Vecchia C (2002): Olive oil consumption and risk of non-fatal myocardial infarction in Italy. Int. J. Epidemiol. 31, 1274–1277.
Bosetti C, Gallus S, Trichopoulou A, Talamini R, Franceschi S, Negri E & La Vecchia C (2003): Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract. Cancer Epidemiol. Biomarkers Prev. 12, 1091–1094.
Decarli A, Franceschi S, Ferraroni M, Gnagnarella P, Parpinel MT, La Vecchia C, Negri E, Salvini S, Falcini F & Giacosa A (1996): Validation of a food-frequency questionnaire to assess dietary intakes in cancer studies in Italy. Results for specific nutrients. Ann. Epidemiol. 6, 110–118.
Fernandez E, Negri E, La Vecchia C & Franceschi S (2000): Diet diversity and colorectal cancer. Prev. Med. 31, 11–14.
Franceschi S, Barbone F, Negri E, Decarli A, Ferraroni M, Filiberti R, Giacosa A, Gnagnarella P, Nanni O, Salvini S & La Vecchia C (1995a): Reproducibility of an Italian food frequency questionnaire for cancer studies Results for specific nutrients. Ann. Epidemiol. 5, 69–75.
Franceschi S, Favero A, La Vecchia C, Negri E, Dal Maso L, Salvini S, Decarli A & Giacosa A (1995b): Influence of food groups and food diversity on breast cancer risk in Italy. Int. J. Cancer 63, 785–789.
Gallus S, Bosetti C, Negri E, Talamini R, Montella M, Conti E, Franceschi S & La Vecchia C (2003): Does pizza protect against cancer? Int. J. Cancer 107, 283–284.
Giugliano D, Nappo F & Coppola L (2001): Pizza and vegetables don't stick to the endothelium. Circulation 104, E34–E35.
Hu FB & Willett WC (2002): Optimal diets for prevention of coronary heart disease. JAMA 288, 2569–2578.
Hu FB (2003): Plant-based foods and prevention of cardiovascular disease: an overview. Am. J. Clin. Nutr. 78 (Suppl), 544S–551S.
Kant AK, Schatzkin A, Harris TB, Ziegler RG & Block G (1993): Dietary diversity and subsequent mortality in the First National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am. J. Clin. Nutr. 57, 434–440.
Kant AK, Schatzkin A & Ziegler RG (1995): Dietary diversity and subsequent cause-specific mortality in the NHANES I epidemiologic follow-up study. J. Am. Coll. Nutr. 14, 233–238.
La Vecchia C, Munoz SE, Braga C, Fernandez E & Decarli A (1997): Diet diversity and gastric cancer. Int. J. Cancer 72, 255–257.
Salvini S, Parpinel M, Gnagnarella P, Maisonneuve P & Turrini A ed. (1998): Banca dati di composizione degli alimenti per studi epidemiologici in Italia. Milan, Italy: Istituto Europeo di Oncologia (IEO). p. 121 (ISBN 88-900271-0-X/WWW. IEO.IT).
Sesso HD, Liu S, Gaziano JM & Buring JE (2003): Dietary lycopene, tomato-based food products and cardiovascular disease in women. J. Nutr. 133, 2336–2341.
Tavani A, Gallus S, Negri E & La Vecchia C (2002): Milk, dairy products, and coronary heart disease. J. Epidemiol. Commun. Health 56, 471–472.
Tavani A, Pelucchi C, Negri E, Bertuzzi M & La Vecchia C (2001): n-3 Polyunsaturated fatty acids, fish, and nonfatal acute myocardial infarction. Circulation 104, 2269–2272.
Trichopoulou A, Costacou T, Bamia C & Trichopoulos D (2003): Adherence to a Mediterranean diet and survival in a Greek population. N. Engl. J. Med. 348, 2599–2608.
Verschuren WM, Jacobs DR, Bloemberg BP, Kromhout D, Menotti A, Aravanis C, Blackburn H, Buzina R, Dontas AS, Fidanza F, Karvonen MJ, Nedeljković S, Nissinen A & Toshima H (1995): Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study. JAMA 274, 131–136.
This work was partially supported by Italian ‘Ministero della Salute’ (Contract no. 177, RF 2001). We thank Dr Patrizia Gnagnarella for assistance on nutritional aspects and Mrs M Paola Bonifacino for editorial assistance.
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Gallus, S., Tavani, A. & Vecchia, C. Pizza and risk of acute myocardial infarction. Eur J Clin Nutr 58, 1543–1546 (2004). https://doi.org/10.1038/sj.ejcn.1601997
- acute myocardial infarction
- cardiovascular disease
- case–control study
- Mediterranean diet