Abstract
Objectives: The purpose of this paper was to evaluate the use of air displacement plethysmography (ADP) in children and adolescents with cystic fibrosis (CF). Specifically, the primary aim of this study was to compare estimates of fat-free mass (FFM) measured from ADP and dual energy X-ray absorptiometry (DEXA) in children and adolescents with CF. The secondary aim was to compare the effect of using predicted thoracic gas volume (VTG) and measured VTG for the calculation of FFM by ADP in this population.
Methods: Cross-sectional FFM measurements were taken using ADP and DEXA in 52 children and adolescents with CF, ranging in age from 6.3 to 16.6 y.
Results: Bland–Altman analysis showed that ADP values of FFM were on average 0.59 kg higher than DEXA values (95% limits of agreement = 3.61 to −2.43 kg); however this difference was not significant. There was no significant correlation (r=−0.26, P=0.07) between the mean FFM and difference in FFM between ADP and DEXA. Using either predicted or measured VTG did not significantly affect FFM estimates in individuals with CF who had normal lung function (bias=−0.39±0.86 kg; r=−0.02, P=0.93).
Conclusions: ADP is an appropriate technique for use in children and adolescents with CF.
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We thank the Royal Children's Hospital Foundation for their financial support.
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Guarantor: AJ Murphy.
Contributors: AJM was responsible for study design, performing the ADP measurements, interpreting the results and writing of the paper. HMB was responsible for study design, coordinating the study and editing the paper. JCHW supervised the DEXA measurements and participated in editing the paper. CEW contributed to original study design, supervision of clinical aspects and editing of the paper. RMG participated in study design and editing of the paper. PSWD was involved in the study design, interpretation of the results and editing of the paper.
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Murphy, A., Buntain, H., Wong, J. et al. The use of air displacement plethysmography in children and adolescents with cystic fibrosis. Eur J Clin Nutr 58, 985–989 (2004). https://doi.org/10.1038/sj.ejcn.1601919
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DOI: https://doi.org/10.1038/sj.ejcn.1601919