Abstract
Water balance depends essentially on fluid intake and urine excretion. Mild dehydration and the consequent hypertonicity of the extracellular fluid induce an increase in vasopressin secretion, thus stimulating urine concentrating processes and the feeling of thirst. The osmotic threshold for the release of vasopressin is lower than that for thirst and also shows appreciable individual variation. Sustained high levels of vasopressin and low hydration induce morphological and functional changes in the kidney. However, they could also be risk factors in several renal disorders, such as chronic renal failure, diabetic nephropathy and salt-sensitive hypertension.
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References
Anastasio P, Cirillo M, Spitali L, Frangiosa A, Pollastro RM & DeSanto NG (2001): Level of hydration and renal function in healthy humans. Kidney Int. 60, 748–756.
Andersen LJ, Andersen JL, Schütten HJ, Warberg J & Bie P (1990): Antidiuretic effect of subnormal levels of arginine vasopressin in normal humans. Am. J. Physiol. 259, R53–R60.
Bagnasco SM, Peng T, Janech MG, Karakashian A & Sands JM (2001): Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am. J. Physiol. Renal Physiol. 281, F400–F406.
Bankir L (2001): Antidiuretic action of vasopressin: quantitative aspects and interaction between V1a and V2 receptor-mediated effects. Cardiovas. Res. 51, 372–390.
Bankir L, Bardoux P & Ahloulay M (2001): Vasopressin and diabetes mellitus. Nephron 87, 8–18.
Bankir L & Kriz W (1995): Adaptation of the kidney to protein intake and to urine concentrating activity: similar consequences in health and CRF. Kidney Int. 47, 7–24.
Bankir L, Niesor R & Bouby N (1995): Sodium excretion is impaired by high urinary concentration. FASEB J. 9, A5.
Bankir L, Pouzet B, Choukroun G, Bouby N, Schmitt F & Mallie JP (1998): Concentrer l'urine ou excréter le sodium: deux exigences parfois contradictoires. Néphrologie 19, 203–209.
Bankir L & Trinh-Trang-Tan MM (2000): Renal urea transporters. Direct and indirect regulation by vasopressin. Exp. Physiol. 85, 243S–252S.
Bardoux P, Bruneval P, Heudes D, Bouby N & Bankir L (2003): Diabetes-induced albuminuria: role of antidiuretic hormone as revealed by chronic V2 receptor antagonism in the rat. Nephrol. Dial. Transplant. 18, 1755–1763.
Bardoux P, Martin H, Ahloulay M, Schmitt F, Bouby N, Trinh-Trang-Tan MM & Bankir L (1999): Vasopressin contributes to hyperfiltration, albuminuria, and renal hypertrophy in diabetes mellitus: study in vasopressin-deficient Brattleboro rats. Proc. Natl. Acad. Sci. USA 96, 10397–10402.
Berl T & Robertson GL (2000): Pathophysiology of water metabolism. In The Kidney. ed. BM Brenner, pp 866–924. Philadelphia: Saunders.
Blot-Chabaud M, Laplace M, Cluzeaud F, Capurro C, Cassingéna R, Vandewalle A, Farman N & Bonvalet JP (1996): Characteristics of a rat cortical collecting duct cell line that maintains high transepithelial resistance. Kidney Int. 50, 367–376.
Bouby N, Ahloulay M, Nsegbe E, Déchaux M, Schmitt F & Bankir L (1996): Vasopressin increases glomerular filtration rate in conscious rats through its antidiuretic action. J. Am. Soc. Nephrol. 7, 842–851.
Bouby N, Bachmann S, Bichet D & Bankir L (1990): Effect of water intake on the progression of chronic renal failure in the 5/6 nephrectomized rat. Am. J. Physiol. (Renal Fluid Electrolyte Physiol. 27) 258, F973–F979.
Bouby N, Hassler C & Bankir L (1999): Contribution of vasopressin to progression of chronic renal failure: study in Brattleboro rats. Life Sci. 65, 991–1004.
Bregman R, Boim MA, Santos OFP, Ramos OL & Schor N (1990): Effects of systemic hypertension, antidiuretic hormone, and prostaglandins on remnant nephrons. Hypertension 15(Suppl 1), I.72–I.75.
Choukroun G, Schmitt F, Martinez F, Drüeke TB & Bankir L (1997): Low urine flow reduces the capacity to excrete a sodium load in humans. Am. J. Physiol. (Regulatory Integrative Comp. Physiol. 42) 273, R1726–R1733.
Djelidi S, Fay M, Cluzeaud F, Escoubet B, Eugene E, Capurro C, Bonvalet JP, Farman N & Blot-Chabaud M (1997): Transcriptional regulation of sodium transport by vasopressin in renal cells. J. Biol. Chem. 272, 32919–32924.
Ecelbarger CA, Kim GH, Terris J, Masilamani S, Mitchell C, Reyes I, Verbalis JG & Knepper MA (2000): Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am. J. Physiol.—Renal Physiol. 279, F46–F53.
Fernandes S, Bruneval P, Hagege A, Heudes D, Ghostine S & Bouby N (2002): Chronic V2-vasopressin receptor stimulation increases basal blood pressure and exacerbates deoxycorticosterone acetate–salt hypertension. Endocrinology 143, 2759–2766.
Gellai M, Silverstein JH, Hwang JC, LaRochelle FT & Valtin H (1984): Influence of vasopressin on renal hemodynamics in conscious Brattleboro rats. Am. J. Physiol. (Renal Fluid Electrolyte Physiol. 15) 246, F819–F827.
Hadj-Aissa A, Bankir L, Fraysse M, Bichet DG, Laville M, Zech P & Pozet N (1992): Influence of the level of hydration on the renal response to a protein meal. Kidney Int. 42, 1207–1216.
Ishibashi K, Sasaki S, Fushimi K, Yamamoto T, Kuwahara M & Marumo F (1997): Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts. Am. J. Physiol. 272, F235–F241.
Kim GH, Ecelbarger CA, Mitchell C, Packer RK, Wade JB & Knepper MA (1999): Vasopressin increases Na–K–2Cl cotransporter expression in thick ascending limb of Henle's loop. Am. J. Physiol. 276, F96–F103.
Knepper MA & Star RA (1990): The vasopressin-regulated urea transporter in renal inner medullary collecting duct. Am. J. Physiol. 259, F393–F401.
Kwon TH, Hager H, Nejsum LN, Andersen ML, Frokiaer J & Nielsen S (2001): Physiology and pathophysiology of renal aquaporins. Semin. Nephrol. 21, 231–238.
Lifton RP (1996): Molecular genetics of human blood pressure variation. Science 272, 676–680.
Matsuguchi H, Schmid PG, Van-Orden D & Mark AL (1981): Does vasopressin contribute to salt-induced hypertension in the Dahl strain? Hypertension 3, 174–181.
Merrill DC, Skelton MM & Cowley Jr AW (1986): Humoral control of water and electrolyte excretion during water restriction. Kidney Int. 29, 1152–1161.
Morel F, Imbert-Teboul M & Chabardes D (1987): Receptors to vasopressin and other hormones in the mammalian kidney. Kidney Int. 31, 512–520.
Murillo-Carretero MI, Ilundain AA & Echevarria M (1999): Regulation of aquaporin mRNA expression in rat kidney by water intake. J. Am. Soc. Nephrol. 10, 696–703.
Nicco C, Wittner M, DiStefano A, Jounier S, Bankir L & Bouby N (2001): Chronic exposure to vasopressin upregulates ENaC and sodium transport in the rat renal collecting duct and lung. Hypertension 38, 1143–1149.
Pedersen RS, Bentzen H, Bech JN & Pedersen EB (2001): Effect of water deprivation and hypertonic saline infusion on urinary AQP2 excretion in healthy humans. Am. J. Physiol. Renal Physiol. 280, F860–F867.
Robertson GL (1984): Abnormalities of thirst regulation. Kidney Int. 25, 460–469.
Rossier BC (1997): Cum grano salis: the epithelial sodium channel and the control of blood pressure. J. Am. Soc. Nephrol. 8, 980–992.
Tomita K, Pisano JJ & Knepper MA (1985): Control of sodium and potassium transport in the cortical collecting duct of the rat. J. Clin. Invest. 76, 132–136.
Verrey F (1994): Antidiuretic hormone action in A6 cells: effect on apical Cl and Na conductances and synergism with aldosterone for NaCl reabsorption. J. Membr. Biol. 138, 65–76.
Walter SJ, Tennakoon V, McClune JA & Shirley DG (1996): Role of volume status in vasopressin-induced natriuresis: studies in Brattleboro rats. J. Endocrinol. 151, 49–54.
Yagil C, Ben-Ishay D & Yagil Y (1996): Disparate expression of the AVP gene in Sabra hypertension-prone and hypertension-resistant rats. Am. J. Physiol. (Renal Fluid Electrolyte Physiol. 40) 271, F806–F813.
Yamamoto T, Sasaki S, Fushimi K, Kawasaki K, Yaoita E, Oota K, Hirata Y, Marumo F & Kihara I (1995): Localization and expression of a collecting duct water channel, aquaporin, in hydrated and dehydrated rats. Exp. Nephrol. 3, 193–201.
Zerbe RL, Miller JZ & Robertson GL (1991): The reproducibility and heritability of individual differences in osmoregulatory function in normal human subjects. J. Lab. Clin. Med. 117, 51–59.
Zhang X, Hense HW, Riegger GAJ & Schunkert H (1999): Association of arginine vasopressin and arterial blood pressure in a population-based sample. J. Hypertens. 17, 319–324.
Acknowledgements
We thank L Bankir for fruitful scientific discussions, and Carole Nicco and Pascale Bardoux, PhD students, who performed some of the work reported in this paper.
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Guarantor: N Bouby
Contributors: NB was primarily responsible for the writing of the paper. SF took part in the acquisition of some experimental data and preparation of the paper.
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Bouby, N., Fernandes, S. Mild dehydration, vasopressin and the kidney: animal and human studies. Eur J Clin Nutr 57 (Suppl 2), S39–S46 (2003). https://doi.org/10.1038/sj.ejcn.1601900
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DOI: https://doi.org/10.1038/sj.ejcn.1601900
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