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The effect of grape-seed extract on 24 h energy intake in humans

European Journal of Clinical Nutrition volume 58, pages 667–673 (2004)Cite this article

Abstract

Objective: Since grape-seed extract has been shown to stimulate lipolysis in vitro and reduce food intake in rats, we assessed the efficacy of grape-seed extract with respect to energy intake (EI) and satiety.

Design: In a randomized, placebo-controlled, double-blind, cross-over study, 51 subjects (age 18–65 y, body mass index 22–30 kg/m2) ate an ad libitum lunch and dinner twice in the University Restaurant for 3 days. Standard breakfasts and snacks were provided. Supplements were taken 30–60 min prior to each meal.

Results: In the total study population, no difference in 24 h EI was found between the grape-seed extract and placebo. However, in the subgroup of subjects (n=23) with an energy requirement ≥the median of 7.5 MJ/day, EI was reduced by 4% (ΔEI 352.1 kJ/24 h, P=0.05) after grape-seed extract compared to placebo treatment. Meanwhile, there were no significant differences in macronutrient composition, attitude towards eating, satiety, mood or tolerance.

Conclusions: Grape seed reduced 24 h EI, with on average 4% in subjects who had an energy requirement ≥7.5 MJ/day, without further effects on satiety, mood or tolerance. These findings suggest that grape seed could be effective in reducing 24 h EI in normal to overweight dietary unrestrained subjects, and could, therefore, play a significant role in body-weight management.

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  1. Maastricht University, Human Biology, Maastricht, The Netherlands

    N Vogels, I M T Nijs & M S Westerterp-Plantenga

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  1. N Vogels
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  2. I M T Nijs
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Vogels, N., Nijs, I. & Westerterp-Plantenga, M. The effect of grape-seed extract on 24 h energy intake in humans. Eur J Clin Nutr 58, 667–673 (2004). https://doi.org/10.1038/sj.ejcn.1601863

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