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Possible roles of magnesium on the immune system

Abstract

During the last few years, magnesium (Mg) has been subject of research due to its functionality in the organism. It is one of the most important micronutrients, and therefore its role in biological systems has been extensively investigated. Particularly, Mg has a strong relation with the immune system, in both nonspecific and specific immune response, also known as innate and acquired immune response. The aim of this paper is to review the state of the art about the interactions between Mg and the immune system. We discuss the link between dietary Mg and inflammation, apoptosis and alterations in number and function of innate immune cell populations, described in animal models. Furthermore, the immune system can be compromised in human populations under certain circumstances, including athletes and elderly people. The importance of a balanced Mg homeostasis and its interaction with the immune system in these groups has also been reviewed. Although emerging data support the relevant role of Mg in the immune response, further research is needed; and special efforts should be made to establish the most adequate dose in nutritional supplements to reach beneficial effects on health.

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References

  • Black S, Yu H, Lee J, Sachchithananthan M & Medcalf R (2001): Physiologic concentrations of magnesium and placental apoptosis: prevention by antioxidants. Obstet. Giynec. 98, 319–322.

    CAS  Google Scholar 

  • Bussiere FI, Gueux E, Rock E, Girardeau JP, Tridon A, Mazur A & Rayssiguier Y (2002): Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration. Br. J. Nutr. 87, 107–113.

    Article  CAS  Google Scholar 

  • Bussière L, Mazur A, Gueux E, Nowacki W & Rayssiguier Y (1995): Trigliceride-rich lipoproteins from magnesium-deficient rats are more susceptible to oxidation by cells and promote proliferation of cultured vascular smooth muscle cells. Magnesium Res. 8, 151–158.

    Google Scholar 

  • Chien MM, Zahradka KE, Newell MK & Freed JH (1999): Fas-induced B cell apoptosis requires an increase in free cytosolic magnesium as an early event. J. Biol. Chem. 274, 7059–7066.

    Article  CAS  Google Scholar 

  • Fantidis P, Cacho JR, Marin M, Jarabo RM, Solera J & Herrero E (1995): Intracellular (polymorphonuclear) magnesium content in patients with bronchial asthma between attacks. J. Roy Soc. Med. 88, 441–445.

    CAS  PubMed  Google Scholar 

  • Galland L (1988): Magnesium and immune function: an overview. Magnesium 7, 290–299.

    CAS  PubMed  Google Scholar 

  • Ginniakis C, Forbes IJ & Zalewski PD (1991): Calcium/magnesium dependent nuclease: tissue distribution, relationship to inter-nucleosomal DNA fragmentation and inhibition by zinc. Biochem. Biophys. Res. Commun. 181, 915–920.

    Article  Google Scholar 

  • Hill J, Micklewright A, Lewis S & Britton J (1997): Investigation of the effect of short-term change in dietary magnesium intake in asthma. Eur. Respir. J. 10, 2225–2229.

    Article  CAS  Google Scholar 

  • Ishiguro S, Miyamoto A, Tokushima T, Ueda A & Nishio A (2000): Low extracellular Mg2+ concentrations suppress phagocytosis in vitro by alveolar macrophages from rats. Magnesium Res. 13, 11–18.

    CAS  Google Scholar 

  • Ishizaka K, Tomioka H & Ishizaka T (1970): Mechanisms of passive sensitization: I. Presence of IgE molecules on human leukocytes. J. Immunol. 105, 1459–1467.

    CAS  PubMed  Google Scholar 

  • Kabashima H, Nagata K, Maeda K & Iijima T (2002): Involvement of substance P, mast cells, TNF alpha and ICAM-1 in the infiltration of inflammatory cells in human periapical granulomas. Oral Pathol. Med. 83, 175–180.

    Article  Google Scholar 

  • Konig D, Weinstock C, Keul J, Northoff H & Berg A (1998): Zinc, iron, and magnesium status in athletes–influence on the regulation of exercise-induced stress and immune function. Exerc. Immunol. Rev. 4, 2–21.

    CAS  PubMed  Google Scholar 

  • Levine BS & Coburn JW (1984): Magnesium the mimic/antagonist of calcium. N. Engl. J. Med. 310, 1253–1255.

    Article  CAS  Google Scholar 

  • Maier JAM, Malpuec-Brugère C, Rock E, Rayssiguier Y & Mazur A (1997): Serum from magnesium-deficient rats affects endothelial cells in culture: role of hyperlipemia and inflammation. J. Nutr. Biochem. 9, 17–22.

    Article  Google Scholar 

  • Mak IT, Dickens BF, Komarov AM, Wagner TL, Phillips TM & Weckegli WB (1997): Activation of the neutrophil and loss of plasma glutathione during Mg deficiency—modulation by nitric oxide synthase inhibition. Mol. Cell. Biochem. 176, 35–39.

    Article  CAS  Google Scholar 

  • Malpuech-Brugère C, Kuryszko J, Nowacki W, Rock E, Raysiguier Y & Mazur A (1998): Early morphological and immunological alterations in the spleen during magnesium deficiency in the rat. Magnesium Res. 11, 161–169.

    Google Scholar 

  • Malpuech-Brugère C, Nowacki W, Daveau M, Gueux E, Linard Ch, Rock E, Lebreton JP, Mazur A & Rayssiguier Y (2000): Inflammatory response following acute magnesium deficiency in the rat. Biochim. Biophys. Acta. 1501, 91–98.

    Article  Google Scholar 

  • Malpuech-Brugère C, Nowacki W, Gueux E, Kuryszko J, Rock E, Rayssiguier Y & Mazur A (1999): Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress. Br. J. Nutr. 81, 405–411.

    PubMed  Google Scholar 

  • McCoy H & Kenney MA (1996): Interactions between magnesium and vitamin D: possible implications in the immune system. Magnesium Res. 9, 185–203.

    CAS  Google Scholar 

  • Mircetic RN, Dodig S, Raos M, Petres B & Cepelak I (2001): Magnesium concentration in plasma, leukocytes and urine of children with intermittent asthma. Clin. Chim. Acta 312, 197–203.

    Article  CAS  Google Scholar 

  • Monteleone CA & Sherman AR (1997): Nutrition and asthma. Arch. Int. Med. 157, 23–34.

    Article  CAS  Google Scholar 

  • Nieman DC (1998): Exercise and resistance to infection. Can. J. Physiol. Pharmacol. 76, 573–580.

    Article  CAS  Google Scholar 

  • Nova E, Montero A, López-Varela S & Marcos A (2001): Are elite gymnasts under malnutrition conditions. Evaluation of diet, anthropometric and immunocompetence. Nutr. Res. 21, 15–29.

    Article  CAS  Google Scholar 

  • Pedersen BK, Bruunsgaard H, Jensen M, Toft AD, Hansen H & Ostrowski K (1999): Exercise and the immune system influence of nutrition and aging. J. Sci. Med. Sport. 2, 234–252.

    Article  CAS  Google Scholar 

  • Pedersen BK, Rohde T & Zacho M (1996): Immunity in athletes. J. Sports. Med. Phys. Fitness 36, 236–245.

    CAS  PubMed  Google Scholar 

  • Petrault I, Zimowska W, Mathieu J, Bayle D, Rock E, Favier A, Rayssiguier Y & Mazur A (2002): Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency. Biochem. Biophys. Acta 1586, 92–98.

    CAS  PubMed  Google Scholar 

  • Rayssiguier Y, Durlach J, Guex E, Rock E & Mazur A (1993): Magnesium and aging I. Experimental data: importance of oxidative damage. Magnesium Res. 6, 369–378.

    CAS  Google Scholar 

  • Rolla G, Bucca C, Bugiania M, Arissa W & Spinaci S (1987): Reduction of histamine-induced bronchoconstriction by magnesium in asthmatic subject. Allergy 42, 186–188.

    Article  CAS  Google Scholar 

  • Sharp NC & Koutedakis Y (1992): Sport and the overtraining syndrome: immunological aspects. Br. Med. Bull. 48, 518–533.

    Article  CAS  Google Scholar 

  • Speich M, Pineau A & Ballereau F (2001): Minerals, trace elements and related biological variables in athletes and during physical activity. Clin. Chim. Acta 312, 1–11.

    Article  CAS  Google Scholar 

  • Weglicki WB, Phillips TM, Freedman AM, Cassidy MM & Dickens BF (1992): Magnesium deficiency elevates circulating levels of inflammatory cytokines and endothelia. Mol. Cell. Biochem. 110, 169–173.

    Article  CAS  Google Scholar 

  • Weglicki WB & Phillips TM (1992): Pathobiology of magnesium deficiency: a cytokine/neurogenic inflammation hypothesis. Am. J. Physiol. 263, R734–R737.

    CAS  PubMed  Google Scholar 

  • Weglicki WB, Dickens BF, Wagner TL, Chmielinska JJ & Phillips TM (1996): Immunoregulation by neuropeptides in magnesium deficiency ex vivo effect of enhanced substance P production on circulating T lymphocytes from magnesium-deficient mice. Magnesium Res. 9, 3–11.

    CAS  Google Scholar 

  • Widlak P & Garrard WT (2001): Ionic and cofactor requirements for the activity of the apoptotic endonuclease DFF40/CAD. Mol. Cell. Biochem. 218, 125–130.

    Article  CAS  Google Scholar 

  • Yamamoto J, Watanabe S, Hirose M, Osada T, Ra C & Sato N (1999): Role of mast cells as a trigger of inflammation in Helicobacter pylori infection. J. Physiol. Pharmacol. 50, 17–23.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

Miguel Tam wishes to thank all the members of Dr. Marcos' team for providing a wonderful work environment and making the lab a very pleasant place during the period Nov 2001–May 2002.

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Correspondence to A Marcos.

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Tam, M., Gómez, S., González-Gross, M. et al. Possible roles of magnesium on the immune system. Eur J Clin Nutr 57, 1193–1197 (2003). https://doi.org/10.1038/sj.ejcn.1601689

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