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Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study


Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen.

Design: Randomized, diet-controlled, cross-over study.

Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands.

Subjects: Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully.

Interventions: Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects.

Results: Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P=0.02) and 12.4% (P≤0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption.

Conclusions: Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk.

Sponsorship: Dutch Foundation for Alcohol Research (SAR).

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We acknowledge all those involved in the conduct of the study and thank the volunteers for their enthusiastic participation.

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Correspondence to HFJ Hendriks.

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Sierksma, A., van der Gaag, M., Kluft, C. et al. Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study. Eur J Clin Nutr 56, 1130–1136 (2002).

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  • alcohol
  • atherosclerosis
  • inflammation
  • C-reactive protein
  • fibrinogen

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