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The comparative gastrointestinal responses of children and adults following consumption of sweets formulated with sucrose, isomalt and lycasin HBC

European Journal of Clinical Nutrition volume 56, pages 755–764 (2002)Cite this article

Abstract

Objectives: To determine the gastrointestinal responses of children and adults following consumption of sucrose, isomalt and lycasin HBC and to compare these at two different dose levels in adults.

Design: Both studies were randomised, double-blind, cross-over designs.

Subjects: Fifty-one children aged 6–9 y were recruited from primary schools in the Salford area of Greater Manchester. Forty-eight children completed the study. Fifty healthy adult volunteers aged 18–24 y were recruited from the student population of the University of Salford. All subjects completed the study.

Interventions: Children consumed either 25 g of sucrose, isomalt or lycasin HBC and adults 25 and 40 g in hard boiled sweets per day for two consecutive test days. Test periods of 2 days were separated by 7 day washout periods. Children consumed sweets throughout test days and adults in no less than 30 min but no more than 90 min. Subjects reported the prevalence and magnitude of flatulence, borborygmi, bloating, colic, bowel movements and watery faeces.

Results: Consumption of 25 g isomalt provoked a mild laxative effect in children but not in adults. Consumption of 25 g isomalt significantly increased the prevalence and magnitude of gastrointestinal responses in both children and adults. Consumption of 25 g lycasin HBC significantly increased borborygml in children and adults but no other gastrointestinal responses. Consumption of 40 g lycasin HBC or isomalt by adults significantly increased the mean frequency of bowel movements and the number of subjects passing watery faeces. In adults, 40 g isomalt and lycasin HBC provoked significantly more gastrointestinal responses compared to 25 g of either product.

Conclusions: Consumption of 25 g lycasin HBC does not provoke an unacceptable laxative effect or gastrointestinal response in children or adults compared to 25 g isomalt, which is associated with a mild laxative effect and increase in gastrointestinal responses. In adults gastrointestinal responses following consumption of products were found to be dose dependent.

Sponsorship: Roquette Frères, Lestrem, France.

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References

  • Adamson A, Rugg-Gunn AJ, Butler T, Appleton DR, Hackett AF . 1992 Dietary sources of energy protein, unavailable carbohydrate and fat in 11–12-year-old English children compared with results in 1980 J. Hum. Nutr. Diet. 5: 371–385

    Article  Google Scholar 

  • Beaugerie L, Flourié B, Marteau P, Pellier P, Franchisseur C, Rambaud JC . 1990 Digestion and absorption in the human intestine of three sugar alcohols Gastroenterology 99: 717–723

    Article  CAS  Google Scholar 

  • Beaugerie L, Flourié B, Pellier P, Achour L, Franchisseur C, Rambaud JC . 1991 Tolerance clinique, absorption intestinale et valeur energetique de quatre polyols pris a jeun Gastroenterol. Clin. Biol. 15: 929–932

    CAS  PubMed  Google Scholar 

  • Bloom DA, Seeley WW, Ritchey ML, McGuire EJ . 1993 Toilet habits and continence in children–an opportunity sampling in search of normal parameters J. Urol. 149: 1087–1090

    Article  CAS  Google Scholar 

  • Cummings JH, Lee A, Storey D . 2001 Workshop: physiology and tolerance of LDCs Br. J. Nutr. 85: S59–S60

    Article  CAS  Google Scholar 

  • Fritz M, Siebert G, Kaspar H . 1985 Dose dependence of breath hydrogen and methane in healthy volunteers after ingestion of a commercial disaccharide mixture Palatinit Br. J. Nutr. 54: 389–400

    Article  CAS  Google Scholar 

  • Gart JJ . 1969 An exact test for comparing matched proportions in cross-over designs Biometrica 56: 75–80

    Article  Google Scholar 

  • Grenby TH, Saldanha MG . 1988 Comparison of lycasin versus sucrose sweets in demineralisation studies of human enamel and hydroxylapatite Caries Res. 22: 269–275

    Article  CAS  Google Scholar 

  • Grupp U, Siebert G . 1978 Metabolism of hydrogenated palatinose, an equimolar mixture of α-D-glucopyranosido-1-6-sorbitol and α-D-glucopyranosido-1-6-mannitol Res. Exp. Med. (Berlin) 173: 261–278

    Article  CAS  Google Scholar 

  • Hyams JS . 1983 Sorbitol intolerance: an unappreciated cause of functional gastrointestinal complaints Gastroenterology 84: 30–33

    CAS  PubMed  Google Scholar 

  • Johnson B, Hackett AF . 1997 Eating habits of 11–14-year-old schoolchildren living in less affluent areas of Liverpool, UK J. Hum. Nutr. Diet. 10: 135–144

    Article  Google Scholar 

  • Koutsou GA, Storey DM, Lee A, Zumbé A, Flourié B, Le Bot Y, Olivier Ph . 1996 Dose-related gastrointestinal response to the ingestion of either isomalt, lactitol or maltitol in milk chocolate Eur. J. Clin. Nutr. 50: 17–21

    CAS  PubMed  Google Scholar 

  • Kruger D, Grossklaus R, Klingebiel L, Ziese T, Kochgensecke S . 1991 Caloric availability of palatinit in the small intestine of rats: implications of dose dependancy on the energy value Nutr. Res. 11: 669–678

    Article  Google Scholar 

  • Langkilde AM, Anderson H, Schweizer TF, Wursch P . 1994 Digestion and absorption of sorbitol, maltitol and isomalt from the small bowel. A study in ileostomy subjects Eur. J. Clin. Nutr. 48: 768–775

    CAS  PubMed  Google Scholar 

  • Lee A, Zumbé A, Storey DM . 1994 Breath hydrogen after ingestion of the bulk sweeteners sorbitol, isomalt and sucrose in chocolate Br. J. Nutr. 71: 731–737

    Article  CAS  Google Scholar 

  • Livesey G . 2001 Tolerance of low-digestible carbohydrates: a general view Br. J. Nutr. 85: S7–S16

    Article  CAS  Google Scholar 

  • Macfarlane GT, Cummings JH . 1991 The colonic flora, fermentation and large bowel function In: The Large Intestine: Physiology, Pathophysiology and Disease ed. SF Phillips, JH Pemberton & RG Shorter, pp 51–92 New York: Raven Press

    Google Scholar 

  • Marteau P, Flourié B . 2001 Tolerance to low-digestible carbohydrates: symptomatology and methods Br. J. Nutr. 85: S17–S21

    Article  CAS  Google Scholar 

  • McNemar Q . 1947 Note on the sampling error of the difference between correlated proportions or percentages Psychometrica 12: 153–157

    Article  CAS  Google Scholar 

  • Menzies IS . 1983 Medical importance of sugars in the alimentary tract In: Developments in Sweeteners–2 ed. TH Grenby, KJ Parker & MG Lindley, pp 89–118 London: Applied Science

    Google Scholar 

  • Nilsson U, Jagerstad M . 1987 Hydrolysis of lactitol, maltitol and palatinit by human intestinal biopsies Br. J. Nutr. 58: 199–206

    Article  CAS  Google Scholar 

  • Paige DM, Bayless TM, Davis LR . 1992 Palatinit digestibility in children Nutr. Res. 12: 27–37

    Article  Google Scholar 

  • Pelletier X, Hanesse B, Bornet F, Debry G . 1994 Glycaemic and insulinaemic responses in healthy volunteers upon ingestion of maltitol and maltitol syrups Diabetes & Metab. 20: 291–296

    CAS  Google Scholar 

  • Saunders DR, Wiggins HS . 1981 Conservation of mannitol, lactulose and raffinose by the human colon Am. J. Physiol. 241: G397–G402

    CAS  PubMed  Google Scholar 

  • Sicard PJ, Le Bot Y . 1994 Manufacturing opportunities with non-sugar sweeteners In: Sugarless–Towards the Year 2000 ed. AJ Rugg-Gunn, pp 112–135 Cambridge: Royal Society of Chemistry

    Google Scholar 

  • Storey DM, Zumbé A . 1996 Physiology, metabolism and tolerance of digestible and low-digestible carbohydrates In: Handbook of Starch Hydrolysis Products and Their Derivatives ed. M Kearsley, pp 178–229 Glasgow: Blackie

    Google Scholar 

  • Storey DM, Koutsou G, Lee A, Zumbé A, Olivier P, Le Bot Y, Flourié B . 1998 Tolerance and breath hydrogen excretion following ingestion of maltitol incorporated at two levels into milk chocolate consumed by healthy young adults with and without fasting J. Nutr. 128: 587–592

    Article  CAS  Google Scholar 

  • Thiebaud D, Jacot E, Schmitz H, Spengler M, Felber JP . 1984 Comparative study of isomalt and sucrose by means of continuous indirect calorimetry Metabolism 33: 808–813

    Article  CAS  Google Scholar 

  • Ziesenitz SC, Siebert G . 1987 The metabolism and utilisation of polyols and other bulk sweeteners compared with sugar In: Developments in Sweeteners, Vol 3 ed. TH Grenby, pp 109–149 Barking: Elsevier

    Google Scholar 

  • Zumbé A, Lee A, Storey DM . 1994 Manufacture and marketing of non-sugar chocolate In: Sugarless–Towards the Year 2000 ed. AJ Rugg-Gunn, pp 147–171 Cambridge: Royal Society of Chemistry

    Google Scholar 

  • Zumbé A, Lee A, Storey DM . 2001 Polyols in confectionery: the route to sugar-free, reduced sugar and reduced calorie confectionery Br. J. Nutr. 88: S31–S45

    Article  Google Scholar 

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Acknowledgements

The investigators thank the children, parents and staff of the Alder Park and Westwood Park County Primary Schools, Salford, Greater Manchester.

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Author notes

  1. A Lee and DM Storey: Guarantor: DM Storey and A Lee

  2. A Lee, D Wils, A Zumbé and DM Storey: Contributors: All authors were equally responsible for initiating and designing the study and writing the report. A Lee collected the data and performed the statistical analysis.

Authors and Affiliations

  1. Bioscience Research Institute, The University of Salford, Greater Manchester, UK

    A Lee, A Zumbé & DM Storey

  2. Roquette Frères, Lestrem, France

    D Wils

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  1. A Lee
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  2. D Wils
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  3. A Zumbé
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Correspondence to DM Storey.

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Lee, A., Wils, D., Zumbé, A. et al. The comparative gastrointestinal responses of children and adults following consumption of sweets formulated with sucrose, isomalt and lycasin HBC. Eur J Clin Nutr 56, 755–764 (2002). https://doi.org/10.1038/sj.ejcn.1601389

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