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Effect of tamarind ingestion on fluoride excretion in humans

European Journal of Clinical Nutrition volume 56, pages 82–85 (2002)Cite this article

Abstract

Objective: To evaluate the effect of tamarind (Tamarindus indicus) ingestion on excretion of fluoride in school children.

Design: Randomized, diet-control study.

Subject: Twenty healthy boys were included and 18 of them completed the study.

Interventions: Each subject consumed 10 g tamarind daily with lunch for 18 days at the social welfare boys' hostel. The nutrient composition of the daily diet was constant throughout the experimental period.

Results: Tamarind intake led to significant increase (P<0.001) in the excretion of fluoride in 24 h urine (4.8±0.22 mg/day) as compared to excretion on control diet (3.5±0.22 mg/day). However, excretion of magnesium and zinc decreased significantly (7.11±1.48 mg of Mg and 252.88±12.84 µg of Zn per day on tamarind diet as compared to 23.39±3.68 mg of Mg and 331.78±35.31 µg Zn per day on control diet). Excretion of calcium and phosphorous were not significantly different while creatinine excretion decreased with tamarind intake (225.66±81 mg creatinine/day with tamarind and 294.5±78.76 mg creatinine/day without tamarind).

Conclusion: Tamarind intake is likely to help in delaying progression of fluorosis by enhancing urinary excretion of fluoride.

Sponsorship: National Institute of Nutrition, Hyderabad, India (ICMR).

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References

  • Allcroft R, Burns KN . 1969 Alleviation of industrial fluorosis in a herd Fluoride 2: 55–59

    Google Scholar 

  • Brudevold F, Moreno E, Bakhos Y . 1972 Fluoride complexes in drinking water Arch. Oral. Biol. 17: 1155–1163

    Article  CAS  Google Scholar 

  • Carald DB, Floriant LC . 1987 Influence of type and level of dietary protein on fluoride bioavailability in rat J. Nutr. 117: 2086–2090

    Article  Google Scholar 

  • Chem PS Jr, Toribara TY, Waner H . 1956 Micro determination of phosphorus Anal. Chem. 28: 1756–1758

    Article  Google Scholar 

  • Ekstrand J, Ehranebo M, Lars O, Boreus MD . 1978 Fluoride bioavailability after intravenous and oral administration: importance of renal clearance and urine flow Clin. Pharmac. Ther. 23: 329–337

    Article  CAS  Google Scholar 

  • Ekstrand J, Ehranebo M, Withford GM, Jamberg PO . 1980 Fluoride pharmacokinetics during acid-base balance changes in man Eur. J. Clin. Pharmac. 18: 189–194

    Article  CAS  Google Scholar 

  • Elsar J, Merad B, Denine R, Reggabi M, Benali M, Alamir B, Rachidi MA . 1979 Effect of fluoride intoxication of several months on homeostasis in rabbit in the presence and absence of an antidote (Boron) Fluoride 12: 136–143

    Google Scholar 

  • Feldman I, Morken D, Hodge HE . 1957 The state of fluoride in drinking water J. Dent. Res. 36: 192–202

    Article  CAS  Google Scholar 

  • Herzberg M, Foldes J, Steinberg R, Menzel J . 1990 Zinc excretion in osteoporotic women J. Bone Miner. Res. 5: 251–257

    Article  CAS  Google Scholar 

  • Hippocrates Y . 1974 New method for direct determination of ‘True’ creatinine Clin. Chem. 20: 1131–1134

    Google Scholar 

  • Jowsey J, Riggs BL . 1978 Effect of concurrent calcium ingestion on intestinal absorption of fluoride Metabolism 27: 971–974

    Article  CAS  Google Scholar 

  • Khandare AL, Uday KP, Lakshmaiah N . 2000 Beneficial effect of tamarind ingestion on fluoride toxicity in dogs Fluoride 33: 33–38

    CAS  Google Scholar 

  • Lakshmaiah N, Srikantia SG . 1977 Fluoride retention in humans on sorghum and rice based diets Indian J. Med. Res. 65: 543–548

    CAS  PubMed  Google Scholar 

  • Lakshmi AV, Lakshmaiah N . 1999 Effect of different cereal based diet on fluoride retention in Rats National seminar on Fluoride Contamination, Fluoride and Defluoridation Techniques Udaypur, February 25–27.

    Google Scholar 

  • Maruthamuthu M, Venkatanarayana R . 1987 Binding of fluoride with tamarind gel Fluoride 20: 109–112

    CAS  Google Scholar 

  • Oner G, Bhaumic B, Bala RM . 1984 Effect of zinc deficiency on serum somatomedin levels and skeletal growth in young rats Endocrinology 114: 1860–1863

    Article  CAS  Google Scholar 

  • Rao GS . 1984 Dietary intake and bioavailability of fluoride A. Rev. Nutr. 4: 115–136

    Article  CAS  Google Scholar 

  • Reddy RD, Lahiri NV, Rao RM, Vendanayakam KN, Ebenezer LN, Suguna RM . 1985 Trial of magnesium compounds in the prevention of skeletal fluorosis. An experimental study Fluoride 18: 135–140

    CAS  Google Scholar 

  • Ruzicka JA, Mrkls L, Rokytova K . 1976 The infuence of salt intake on the incorporation of fluoride into mouse bone Caries Res. 10: 386–389

    Article  CAS  Google Scholar 

  • Spencer H, Osis D, Kramer L, Wiatrowski E, Norris C . 1975 Effect of calcium and phosphorus on fluoride metabolism in man J. Nutr. 105: 733–740

    Article  CAS  Google Scholar 

  • Spencer H, Kramer L, Wiatrowski E, Osis D . 1978 Magnesium–fluoride inter-relationship in man II. Effect of magnesium on fluoride metabolism Am. J. Physiol. 234: E343–E347

    CAS  PubMed  Google Scholar 

  • Sriramachari S . 1983 Crystalloid interaction with particular reference to fluoride ion and its possible implications of fluorosis Everyman's Sci. 1: 194–201

    Google Scholar 

  • Stookey GK, Crane DD, Muhler JC . 1964 Further studies on fluoride absorption Proc. Soc. Exp. Biol. Med. 115: 295–298

    Article  CAS  Google Scholar 

  • Susheela AK . 1999 Fluorosis management programme in India Curr. Sci. 77: 1250–1255

    Google Scholar 

  • Tomotaro D, Kono K, Usuda K, Nishiura H, Tagawa T, Miyat K, Shimahara M, Hashiguchi N, Senda J, Tanaka Y . 2000 Toxicokinetics of intravenous fluoride in rats with renal damage caused by high-dose fluoride exposure Int. Arch. Occupy. Environ. Hlth. 73: 9: S90–S92

    Google Scholar 

  • Tusl T . 1970 Direct determination of fluoride in human urine using fluoride electrode J. Clin. Chem. Acta 27: 216–218

    Article  CAS  Google Scholar 

  • Wagner JJ, Muhler JC . 1960 The effect of calcium and phosphorus on fluoride absorption J. Dent. Res. 39: 49–52

    Article  CAS  Google Scholar 

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Author notes

  1. AL Khandare: Guarantor: AL Khandare.

  2. AL Khandare, GS Rao and N Lakshmaiah: Contributors: ALK formulated the hypothesis, designed and executed the study, and prepared the draft of the paper. GSR did the laboratory assays, and supervised the feeding. NL reviewed the paper and data analysis.

Authors and Affiliations

  1. National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India

    AL Khandare, GS Rao & N Lakshmaiah

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  1. AL Khandare
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  2. GS Rao
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  3. N Lakshmaiah
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Correspondence to AL Khandare.

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Khandare, A., Rao, G. & Lakshmaiah, N. Effect of tamarind ingestion on fluoride excretion in humans. Eur J Clin Nutr 56, 82–85 (2002). https://doi.org/10.1038/sj.ejcn.1601287

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