Letter | Published:

Antagonistic Effect by Certain Growth-Stimulants of the Tuberculostatic Activity of 5-Amino-2-butoxypyridine

Nature volume 160, page 94 (19 July 1947) | Download Citation

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Abstract

The powerful inhibitory action of 5-amino-2-butoxypyridine on the growth of Mycobacteria, which is highly specific for members of that genus, has recently been reported1,2. Strains of M. tuberculosis (including the human-type H37Rv) and M. phlei were inhibited at dilutions of this compound so high as 0·03-0·001 mgm. per cent in Dorset's synthetic or in Proskauer–Beck medium, inoculation being either on the surface by a small piece of pellicle or by a suspension of about 20,000 organisms per ml.

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References

  1. 1.

    , Proc. Soc. Exn. Biol, N.Y., 63, 153 (1946).

  2. 2.

    , , , , and , J. Pharmacol, 89, 153 (1947).

  3. 3.

    , and , J. Exp. Med., 83, 409 (1946).

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Affiliations

  1. National Institute for Medical Research, Hampstead, London, N.W.3. April 23.

    • H. S. FORREST
    • , P. D'ARCY HART
    •  & JAMES WALKER

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https://doi.org/10.1038/160094a0

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