Letter | Published:

Antagonistic Effect by Certain Growth-Stimulants of the Tuberculostatic Activity of 5-Amino-2-butoxypyridine

Naturevolume 160page94 (1947) | Download Citation



The powerful inhibitory action of 5-amino-2-butoxypyridine on the growth of Mycobacteria, which is highly specific for members of that genus, has recently been reported1,2. Strains of M. tuberculosis (including the human-type H37Rv) and M. phlei were inhibited at dilutions of this compound so high as 0·03-0·001 mgm. per cent in Dorset's synthetic or in Proskauer–Beck medium, inoculation being either on the surface by a small piece of pellicle or by a suspension of about 20,000 organisms per ml.

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  1. Feinstone, W. H., Proc. Soc. Exn. Biol, N.Y., 63, 153 (1946).

  2. Feinstone, W. H., Friedman, H. L., Rothlauf, M. V., Kelly, A. M., and Williams, R. D., J. Pharmacol, 89, 153 (1947).

  3. Dubos, R. J., and Davis, B. D., J. Exp. Med., 83, 409 (1946).

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  1. National Institute for Medical Research, Hampstead, London, N.W.3

    • H. S. FORREST
    • , P. D'ARCY HART


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