Hæmagglutinins of the Hæmophilus Group


We have observed that the erythrocytes of man, mouse, fowl and other animals are agglutinated by saline suspensions of Hœmophilus pertussis, parapertussis and bronchisepticus, and also by filtrates and supernates of casein digest broth cultures of these organisms. The effect is neutralized by human and animal immune sera. A characteristic rise and fall in anti-hæmagglutinin titre occurs in the sera of children during the course of whooping cough. The protective power of sera, given parenterally, against lethal intranasal doses of H. pertussis in mice is closely correlated with their anti-hæmagglutinin titres, but not with their content of bacterial agglutinin or antitoxin.

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  1. Dubos, R. J., J. Bact., 43, 77 (1942).

  2. Dubos, R. J., personal communication (1947).

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