Abstract
Objective: This prospective study was designed to assess the relationship between variations of serum Aluminium levels and bone mineralization, which is one of its target tissues, in healthy premature (PT) and fullterm (FT) infants.
Study design: Lumbar spine bone mineral density (BMD) and content (BMC) studied by dual energy X-ray absorptiometry were compared to serum aluminium (S-Al), Ca (S-Ca), P (S-P), osteocalcin, alkaline phosphatase activity (S-AP), and 25 OH Vitamin D (25 OH D) by simple and multiple regressions in healthy PT (n=44) following their hospital discharge and FT (n=82). PT (gestational age at birth (mean±1 s.d.) 32±2 weeks) and FT were 43±39 and 36±32 weeks old respectively.
Results: In PT multiple stepwise regression analysis including gestational age at birth, postconceptional age and postnatal age displayed only a significant correlation between BMD or BMC and postnatal age and a negative one with S-Al. In FT correlations were found between BMD or BMC and age and S-Ca.
Conclusions: In PT, variations in blood Al are associated with developmental delays. Care should be taken to lessen Al levels, even in healthy PT babies.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bouglé, D., Sabatier, J., Bureau, F. et al. Relationship between bone mineralization and aluminium in the healthy infant. Eur J Clin Nutr 52, 431–435 (1998). https://doi.org/10.1038/sj.ejcn.1600582
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ejcn.1600582
Keywords
This article is cited by
-
Vitamin D and Bone Health in Childhood and Adolescence
Calcified Tissue International (2013)
-
There is (still) too much aluminium in infant formulas
BMC Pediatrics (2010)