Letter | Published:

Assay of Cation-Active Antiseptics

Nature volume 160, page 55 (12 July 1947) | Download Citation



The agar-plate or the cylinder-plate method of testing the effectiveness of antiseptics and antibiotics is now a well-known laboratory technique; and it is the basis of quantitative estimations of penicillin and of other antiseptics. There is little doubt that the degree of ‘zoning’ obtained is an excellent criterion of a good chemotherapeutic agent, and Fleming1 considers that this test should be so applied. However, recent experiences in my laboratory indicate that this test is not necessarily a good criterion for cation-active antiseptics of the class of quaternary ammonium salts, such as cetyl trimethyl ammonium bromide (‘Cetavlon’) and cetyl pyridinium ohloride (‘Ceepryn’).

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  1. 1.

    Chem. and Indust., Jan. 20, 1945, p. 18.

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  1. 7 Harley Street, London, W.I. April 17.

    • M. A. PHILLIPS


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