Letter | Published:

Constitution of the Succinate and α-Glycerophosphate Oxidase Systems

Nature volume 160, pages 5253 (12 July 1947) | Download Citation

Subjects

Abstract

The succinate and glycerophosphate dehydrogenases belong to the group of ‘cytoehrome-reducing dehydrogenases’1. In some tissues the succinic system is by far the more active, but in others (for example, rabbit skeletal muscle) the two systems are equally important. Hopkins et al.2 suggested that in the succinoxidase system from heart muscle there was an intermediate factor linking the dehydrogenase with cytoehrome c. Stern and Melnick3 claimed to have separated the factor, although their evidence has been rightly questioned4. Straub5 has shown that an oxidase preparation lacking the factor can be reactivated by a heart-muscle dispersion in which the succinic dehydrogenase and cytoehrome oxidase have been destroyed. Experiments reported below show the existence in liver of a soluble factor which links or makes accessible the succinodehydrogenase to the cytoehrome system. This factor or activator is not necessary for the α-glycerophosphate system.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , Biochem. J., 30, 1489 (1936).

  2. 2.

    , , and , Nature, 143, 556(1939).

  3. 3.

    , and , Nature, 144, 330 (1939).

  4. 4.

    , and , Proc. Roy. Soc., B, 129, 277 (1940).

  5. 5.

    , Z. physiol. Chem., 272, 219 (1941).

  6. 6.

    , and , Biochem. J. 32, 936 (1938).

Download references

Author information

Affiliations

  1. Biochemical Laboratory, Cambridge. April 21.

    • A. O. M. STOPPANI

Authors

  1. Search for A. O. M. STOPPANI in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/160052a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.