Abstract
Objectives: To evaluate energy balance after three isocaloric oral loads of different composition and to establish possible relationships between the substrates oxidative patterns and the modifications of insulin and free fatty acids (FFA) plasma profiles. Design: Each subject received, in a randomized order, three oral loads of 2658±45 kJ (636±11 Kcal) either as glucose, lipids (cream) or a mixture (glucose+cream). Setting: The experiments were performed at the University Hospital of Geneva. Subjects: Ten normal body-weight volunteers. Methods: Energy expenditure (EE) and substrates oxidation were measured by indirect calorimetry during 8 h following each load. Plasma glucose, insulin and FFA were also measured. Results: EE was 1776±107, 1818±125 and 1785±117 KJ over 8 h after glucose, mixed and lipids load, respectively. Glucose oxidation was the highest after oral glucose as compared to mixed and lipids load, while the highest value of lipids oxidation was measured after fat load. A significant relationship linked fat oxidation to plasma FFA (r=0.54, P<0.002) as well as to insulin (r=−0.40, P<0.002). Conclusions: (a) The energetic cost of glucose and fat intake is the same; (2) after each load, the main source of energy corresponds to the substrate administered; (3) both plasma insulin and FFA influence the substrate oxidative patterns observed after each load; (4) alimentary fat may contribute to fat oxidation by maintaining elevated plasma FFA levels.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bobbioni-Harsch, E., Habicht, F., Lehmann, T. et al. Energy expenditure and substrates oxidative patterns, after glucose, fat or mixed load in normal weight subjects. Eur J Clin Nutr 51, 370–374 (1997). https://doi.org/10.1038/sj.ejcn.1600413
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.ejcn.1600413
Keywords
This article is cited by
-
Computational modelling of energy balance in individuals with Metabolic Syndrome
BMC Systems Biology (2019)
-
A Model of NEFA Dynamics with Focus on the Postprandial State
Annals of Biomedical Engineering (2009)
-
Similar weight loss with low-energy food combining or balanced diets
International Journal of Obesity (2000)