Abstract
In order to undergo pupation and emergence, the larva of Aedes œgypti L. is dependent on the presence of ‘folic acid’ in the medium1. The use of water-extracted yeast residue makes it possible to replace the ‘folic acid’ of Williams by synthetic pteroyl-glutamic acid (L. casei liver factor) but not by thymine (in quantities up to 1 gm. per 1. of medium) or by xanthopterin1,2. On the basis of these findings, we have used the metamorphosis of mosquito larvæ as a test for pteroylglutamic acid in liver extracts and urine.
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GOLBERG, L., DE MEILLON, B. & MURRAY, J. Pteroylglutamic Acid in Liver Extracts and Urine. Nature 160, 22–23 (1947). https://doi.org/10.1038/160022a0
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DOI: https://doi.org/10.1038/160022a0
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