Letter | Published:

Pteroylglutamic Acid in Liver Extracts and Urine

Nature volume 160, pages 2223 (05 July 1947) | Download Citation

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Abstract

In order to undergo pupation and emergence, the larva of Aedes œgypti L. is dependent on the presence of ‘folic acid’ in the medium1. The use of water-extracted yeast residue makes it possible to replace the ‘folic acid’ of Williams by synthetic pteroyl-glutamic acid (L. casei liver factor) but not by thymine (in quantities up to 1 gm. per 1. of medium) or by xanthopterin1,2. On the basis of these findings, we have used the metamorphosis of mosquito larvæ as a test for pteroylglutamic acid in liver extracts and urine.

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References

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Author information

Affiliations

  1. South African Institute for Medical Research, Johannesburg. April 13.

    • L. GOLBERG
    • , B. DE MEILLON
    •  & J. F. MURRAY

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DOI

https://doi.org/10.1038/160022a0

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