Abstract
Triphenylethylene1 and several active derivatives2–4 have been shown to possess a prolonged œstrogenic activity provided that a dose well above the threshold is administered. Among these, αα-di-(p-ethoxyphenyl)-β-phenylbromoethylene4 has been especially noted for its considerable prolonged œstrogenic activity when administered orally. A considerable prolonged action has also been noted5 when a dose well above the threshold of diethylstilbœstrol dimethyl ether is administered subcutaneously. Emmens6 has attributed the prolonged action shown on injection of the higher doses of methyl ethers of diethylstilbœstrol and of œstrone to “the slowness with which the body effects hydrolysis of such ethers, without which they cannot be esterified and excreted”.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Robson, J. M., and Schönberg, A. ; Nature, 140, 196 (1937).
Robson, J. M., Schönberg, A. and Fahim, H. A., Nature, 142, 292 (1938).
Robson, J. M., Schönberg, A., Tadros, Wadie, and Fahim, H. A., J. Chem. Soc., 1327 (1940).
Schönberg, A., Robson, J. M., and Tadros, Wadie, Nature, 150, 22 (1942); the name of the third author was inadvertently omitted in this publication.
Dodds, E. C., Golberg, L., Lawson, W., and Robinson, R., Proc. Roy. Soc., B, 127, 140 (1939).
Emmens, C. W., J. Endocrin., 1, 142 (1939).
Robson, J. M., and Ansari, M. Y., J. Pharm. Exp. Ther., 79, 340 (1943).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TADROS, W., ROBSON, J. Highly Active Triphenylethylene Derivatives. Nature 160, 20–21 (1947). https://doi.org/10.1038/160020a0
Issue Date:
DOI: https://doi.org/10.1038/160020a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.