Abstract
THE facility with which pathogenic protozoa and A bacteria may acquire resistance to therapeutic agents, as a result of non-curative treatment of infections by these pathogens, is of profound significance both for the theory and for the practice of chemotherapy. The readiness with which trypano-some species may thus develop resistance to certain types of compound is well known; but malaria parasites in general have hitherto appeared singularly incapable of developing an acquired resistance, although a number of claims to have demonstrated this property have been made. Only one of these claims, that of Fulton and Yorke1, referred to again below, can be incontrovertibly accepted.
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References
Fulton, J. D., and Yorke, W., Ann. Trap. Med. Parasitol., 35, 233 (1941).
Lourie, E. M., Ann. Trap. Med. Parasitol., 29, 421 (1935).
Fulton, J. D., Ann. Trap. Med. Parasitol., 36, 75 (1942).
James, S. P., and Tate, P., Nature, 139, 545 (1937).
Curd, F. H. S., Davey, D. G., and Rose, F. L., Ann. Trop. Med. Parasitol., 39, 157 (1945).
Davey, D. G., Ann. Trop. Med. Parasitol., 40, 52 (1946).
Curd, F. H. S., Davey, D. G., and Rose, F. L., Ann. Trop. Med. Parasitol., 39, 208 (1945).
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WILLIAMSON, J., BERTRAM, D. & LOURIE, E. Effects of Paludrine and Other Antimalarials. Nature 159, 885–886 (1947). https://doi.org/10.1038/159885a0
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DOI: https://doi.org/10.1038/159885a0
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