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Pulmonary Œdema and the Spleen

Abstract

WHILE investigating the pharmacological properties of 2-thio-5-methyl-uracil (thio-thymine), it was noticed that this compound could be given intramuscularly to splenectomized rabbits in a dosage of 100 mgm./kgm. without ill effect, but that a similar dosage when given to normal rabbits invariably produced death from pulmonary œdema ; thus, with normal rabbits, 6/6 dead in 5 days ; with splenectomized rabbits, 0/6 dead after two months, and similar rabbits sacrificed two–three days after injection showed no macroscopic or microscopic signs of pulmonary œdema.

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CULLUMBINE, H., SIMPSON, M. Pulmonary Œdema and the Spleen. Nature 159, 781–782 (1947). https://doi.org/10.1038/159781a0

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