Letter | Published:

Treatment of Myasthenia gravis with Di-isopropylfluorophosphonate

Nature volume 159, pages 680681 (17 May 1947) | Download Citation



A NUMBER of papers have appeared recently dealing with di-isopropylfluorophosphonate, which was prepared by McCombie and Saunders1 in 1941 and found by Adrian, Feldberg and Kilby2 to cause a prolonged inhibition of cholinesterase. One of us (J. H. G.) tested its effect on myasthenia gravis in 1943, but had to abandon the work owing to lack of clinical material. This work was continued by the other, and the object of this letter is to report the results.

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  1. 1.

    , and , Nature, 157, 287 (1946).

  2. 2.

    , , and , Nature, 158, 625 (1946).

  3. 3.

    , , , , , , and , Amer. J. Med. Sci., 212, 641 (1946).

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  1. Pharmacological Laboratory, University of Edinburgh, and University College, London. March 11.

    • J. H. GADDUM
    •  & A. WILSON


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