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Analgesic Activity in Compounds Related to Amidone

Abstract

AMIDONE (dl-2-dimethylamino-4 : 4-diphenylheptan-5-one) or Hoechst 10820 was made and examined by the I.G. workers at Hoechst during the War. Short preliminary accounts of the properties of this compound have appeared in both the British and American literature, where the activities of some analogous compounds are also described1,2,3.

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References

  1. B.I.O.S. Final Report, No. 116, Item No. 24, pp. 51, 56, 65.

  2. Scott, C. C., and Chen, K. K., J. Pharm. Exp. Ther., 87, 63 (1946).

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  3. Scott, C. C., Robbins, R. B., and Chen, K. K., Science, 104, 587 (1946).

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  4. Thorp, R. H., Brit. J. Pharmacol., 1, 113 (1946).

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  5. Gaddum, J. H., J. Physiol., 99, 257 (1941).

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THORP, R., WALTON, E. & OFNER, P. Analgesic Activity in Compounds Related to Amidone. Nature 159, 679–680 (1947). https://doi.org/10.1038/159679a0

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