Abstract
THE common symptoms in rats on a choline-deficient diet are, as is well known, fatty liver, impeded growth, and in young animals renal hæmorrhages (for references see Best1). There has been discussion as to whether the vitamin character of choline is due only to its content of labile methyl groups, or if the lipotropic action has a more specific mechanism. The experiments reported below show that an impairment of oxidative metabolism is an early symptom in choline deficiency.
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References
Best, C. H., and Lucas, C. C., "Vitamins and Hormones", 1, 1 (1943).
Griffith, W. H., and Wade, N. J., J. Biol. Chem., 131, 567 (1939); 132, 627 (1940).
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ABDON, NO., BORGLIN, N. Disturbances in Oxidative Metabolism in Choline Deficiency. Nature 158, 793–794 (1946). https://doi.org/10.1038/158793a0
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DOI: https://doi.org/10.1038/158793a0
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