Letter | Published:

Acceleration of Thrombin Formation by a Plasma Component

Nature volume 158, pages 708709 (16 November 1946) | Download Citation



ACCORDING to Quick1, prothrombin is composed of two components A and B, in combination with calcium. Nolf2 carried out experiments from which he formed a similar conclusion. On the other hand, Seegers, Loomis and Vandenbelt3 used purified preparations and concluded that prothrombin consists of a single substance which can act as thrombin precursor.

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  1. 1.

    , Amer. J. Physiol., 140, 212 (1943).

  2. 2.

    , Arch. Internat. de Pharmacodyn. et de Therap., 70, 5 (1945).

  3. 3.

    , , and , Arch. Biochem., 6, 69 (1945).

  4. 4.

    , and , in the press.

  5. 5.

    , , and , Amer. J. Physiol., 114, 667 (1936).

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  1. Baker Medical Research Institute, Alfred Hospital, Melbourne. Oct. 16.

    • P. FANTL
    •  & M. NANCE


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