Effect of Sulphadiazine on the Metabolism of Aneurin in Animals

Abstract

IT is well established that some of the toxic effects of sulphonamides on animals fed purified diets are caused by inhibition of bacterial synthesis of some B vitamins in the intestine, with consequent development of deficiency states. Few attempts have been made, however, to determine if the sulphonamides have a more fundamental effect on the metabolism of the B vitamins in the animal body. The purpose of the present communication is to make a preliminary report on experiments which suggest that sulphadiazine has an effect on the metabolism of aneurin in the animal body.