Tissue Changes in Experimental Mice Treated with Pentose Nucleotides

Abstract

TISSUE changes in mice injected with a commercial mixture of the four pentose nucleotides of ribonucleic acid have been previously described1. Observations on normal and tumour-bearing mice treated with guanylic, adenylic, cytidylic and uridylic acids have now shown changes in the tissues and blood which are characteristic of the individual nucleotides.

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References

  1. 1

    Parsons, L. D., J. Path, and Bact., 57, 9 (1945).

  2. 2

    Clarkson, J. R., Mayneord, W. V., and Parsons, L. D., J. Path, and Bact., 46, 221 (1938). Mayneord, W. V., and Parsons, L. D., ibid., 45, 35 (1937). Parsons, L. D., ibid., 40, 45 (1935); 43, 1 (1936); 47, 501 (1938); 54, 321 (1942); 55, 397 (1943). Parsons, L. D., and Warren, F. L., ibid., 52, 305 (1941).

  3. 3

    Davidson, J. N., and Waymouth, C., Brit. J. Exp. Path., 25, 164 (1944) and references therein.

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BARKER, G., GULLAND, J. & PARSONS, L. Tissue Changes in Experimental Mice Treated with Pentose Nucleotides. Nature 157, 482–483 (1946) doi:10.1038/157482d0

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