Physiological Activity of a Single Follicle Occurring in an Aberrant Baboon Ovary


THE physiological activity of a single ovarian follicle is difficult to assess because assay of its fluid content does not entirely represent its functional capacity. No account is taken of the hormones within the cells of its wall. In fortuitous circumstances, an aberrant ovary containing but a single large follicle was observed in a baboon from which two complete ovaries, shown by serial section, had been removed in 1940. Subsequent oestrogen experiments, as originally reported1, showed that a daily dose of 0.4 mgm. of aestradiol benzoate was the minimum capable of producing optimum swelling of the sex skin, previously attained by both ovaries. Although these experiments were continued for two and a half years, after the first year bleeding did not occur following the withdrawal of oestrogen in any dose whatsoever.

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  1. 1

    Gillman, J., Endocrin., 31, 172 (1942).

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CULINER, A. Physiological Activity of a Single Follicle Occurring in an Aberrant Baboon Ovary. Nature 157, 443 (1946).

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