Alloxan Diabetes in a Ruminant

Abstract

IN the ruminant, the digestion of cellulose and other related carbohydrates is achieved through the conversion by the symbiotic flora of the paunch to simple fatty acids with the evolution of methane and carbon dioxide. If the fatty acids which are absorbed constitute the animal's main source of energy, it is possible that ruminants have a novel intermediary energy metabolism1 in which sugar may play a subordinate part. It is well known that the concentration of glucose in the blood of sheep and goats is normally much lower than that of animals which do not ruminate. Furthermore, relatively large quantities of insulin are necessary to reduce the blood sugar concentration of ruminants to the low levels which lead to hypoglycæ mic distress2,3. Man and the usual experimental animals go into convulsions in such circumstances; sheep do not go into convulsions, they subside into an apathetic condition followed by coma.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Marston, H. R., "Ann. Rev. Biochem.", 564 (1939).

  2. 2

    Strand, R., Anderson, W., Allcroft, W., Biochem. J., 28, i, 642 (1934).

  3. 3

    Cutler, J., J. Biol. Chem., 106, 653 (1934).

  4. 4

    Shaw Dunn, J., Sheehan, H., and McLetchie, N., Lancet, i, 484 (1943).

  5. 5

    Bailey, C., and Bailey, O., J. Amer. Med. Assoc., 122. 1165 (1943).

  6. 6

    Goldner, M., and Gomori, G., Endocrin., 33, 297 (1943).

  7. 7

    Gomori, G., Amer. J. Path., 17, 395 (1941).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

JARRETT, I. Alloxan Diabetes in a Ruminant. Nature 157, 441–442 (1946). https://doi.org/10.1038/157441d0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.