Antimalarial Activity and Toxicity of a Metabolic Derivative of Quinine


THE preparation and properties of a metabolic product of quinine has previously been described1,2, but the results of the studies on the toxicity and antimalarial activity of this compound were not released for publication at that time.

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  1. 1

    Kelsey, F. E., Geiling, E. M. K., Oldham, F. K., and Dearborn, E. H., J. Pharmacol. and Exp. Ther., 80, 391 (1944).

  2. 2

    Mead, J., and Koepfli, J. B., J. Biol. Chem., 154, 507 (1944).

  3. 3

    Marshall, P. B., Nature, 156, 505 (1945).

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    Marshall, P. B., jun., personal communication.

  5. 5

    Silverman, M., Ceithaml, J., Taliaferro, L. G., and Evans, E. A., jun., J. Infect. Dis., 75, 214 (1944).

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KELSEY, F., OLDHAM, F., CANTRELL, W. et al. Antimalarial Activity and Toxicity of a Metabolic Derivative of Quinine. Nature 157, 440 (1946) doi:10.1038/157440a0

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