Constitution of Strychnine and the Biogenetic Relationship of Strychnine and Quinine

Abstract

IN 1942 we considered the possibility that strychnine has the constitution shown in (I), but were unable to find satisfactory explanations of all the transformation products on this basis. This difficulty is no longer insuperable, and in the light of new data and a critical review we now believe that the structure interprets the whole behaviour of strychnine better than any other.

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References

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    Prelog and Szpilfogel, Experientia, 1, 197 (1945).

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    Warnat, K., Helv. Chim. Acta, 14, 997 (1931). Blount, B. K., and Robinson, R., J. Chem. Soc., 2305 (1932); 595 (1934). Leuchs, H., Ber. deut. chem. Gesell, 70, 1543 (1937), and later papers.

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    Robinson, R., J. Chem. Soc., 111, 885 (1917).

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OPENSHAW, H., ROBINSON, R. Constitution of Strychnine and the Biogenetic Relationship of Strychnine and Quinine. Nature 157, 438 (1946) doi:10.1038/157438a0

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