Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Forced Diuresis during Hydropenia

Abstract

IN a paper which has recently been published, McCance1 described the effects of administering hypertonic salt by mouth and intravenously to a dehydrated person. Volumes of urine up to 7–8 c.c./min. were passed, and this urine had a much lower osmotic pressure than the urine passed by the same person before the salt was given. The concentration of sodium chloride in the urine, however, appeared to be at or near the maximum concentration of which the kidney was capable, and it was suggested that the reabsorption of water in the distal tubules was being limited by the concentration of sodium chloride reached within them, a maximum value being attained when the osmotic pressure was still below the level at which it would become the limiting factor. It has now been shown that this conclusion was incorrect, and that it is the total osmotic pressure which is the limiting factor all the time, but that its limiting or maximal value is related to the minute volume, and falls as the latter rises. The evidence was obtained by such experiments as the following.

References

  1. 1

    McCance, R. A., J. Physiol., 104, 196 (1945).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

HERVEY, G., MCCANCE, R. & TAYLER, R. Forced Diuresis during Hydropenia. Nature 157, 338 (1946). https://doi.org/10.1038/157338a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing