Antimalarial Activity in Tetrahydro-acridones and Related Substances

Abstract

FITCH1 has revealed the discovery by German workers of prophylactic activity in 4-hydroxy-7-methoxy-3-n-heptylquinaldme (I) against avian malaria. We have examined a number of tetrahydro-acridones (II; n = 2), hydroxydihydro-β-quinindenes (II; n = 1) and 4-hydroxyquinolines for prophylactic activity in P. gallinaceum infections in chicks and have found noteworthy activity in certain compounds which, so far as the work has proceeded, conform to type (III), of which (I) and (II) are representative, R' and R" being saturated hydrocarbon residues.

References

  1. 1

    Fitch, W. K., Pharm. J., 182 (Oct. 20, 1945).

  2. 2

    Limpach, L., Ber. dtsch. chem. Ges., 64, [B], 969 (1931).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

STEPHEN, J., TONKIN, I. & WALKER, J. Antimalarial Activity in Tetrahydro-acridones and Related Substances. Nature 156, 629 (1945). https://doi.org/10.1038/156629b0

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.