Antimalarial Activity in Tetrahydro-acridones and Related Substances


FITCH1 has revealed the discovery by German workers of prophylactic activity in 4-hydroxy-7-methoxy-3-n-heptylquinaldme (I) against avian malaria. We have examined a number of tetrahydro-acridones (II; n = 2), hydroxydihydro-β-quinindenes (II; n = 1) and 4-hydroxyquinolines for prophylactic activity in P. gallinaceum infections in chicks and have found noteworthy activity in certain compounds which, so far as the work has proceeded, conform to type (III), of which (I) and (II) are representative, R' and R" being saturated hydrocarbon residues.


  1. 1

    Fitch, W. K., Pharm. J., 182 (Oct. 20, 1945).

  2. 2

    Limpach, L., Ber. dtsch. chem. Ges., 64, [B], 969 (1931).

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STEPHEN, J., TONKIN, I. & WALKER, J. Antimalarial Activity in Tetrahydro-acridones and Related Substances. Nature 156, 629 (1945).

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