Abstract
MY communication on this subject was written in ignorance of the work of Barton, Cook and Loudon, which was partly disclosed at a meeting of the Chemical Society, but is still unpublished. In relation to the facts known when I wrote, my remarks on the nature of ring B in colchicine can scarcely be described as unduly speculative. In any event I reserve any possible discussion for the time when all the facts are available. This question of the structure of ring B is, of course, important, but it can be settled by application of routine methods of alkaloid chemistry. On the other hand, the suggestion I have ventured to make regarding ring C is quite novel in this field.
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References
Crigee, Ber., 64, 265 (1931).
Dewar, Nature, 155, 50 (1945).
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Birkinshaw and Raistrick, Biochem. J., 26, 441 (1932). Barger and Dorrer, ibid., 28, 11 (1934).
Birkinshaw, Chambers and Raistrick, Biochem. J., 36, 242 (1942).
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DEWAR, M. [Letters to Editor]. Nature 155, 479 (1945). https://doi.org/10.1038/155479b0
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DOI: https://doi.org/10.1038/155479b0
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