Formation of Creatinine in the Animal Body


H. Borsook and J. W. Dubnoff1 have discovered that phosphoereatine is changed into creatinine in water solution at 38° and pH 7, by splitting off phosphate, and they consider that this spontaneous reaction is the way in which creatinine is formed in the animal body. In connexion with this important discovery, I want to direct attention to similar results which I published in 1940, and which for obvious reasons did not reach any abstracting journal published abroad.

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  1. 1

    Borsook and Dubnoff, "Annual Review of Biochemistry",12, 187 (1943).

  2. 2

    Rosengart, V., Bull. Med. Coll., Dnepropetrovsk, U.S.S.R., 2, 87 (1940) (in Russian).

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