Production of 'Endomitosis' in Bean Roots and its Bearing on the Genesis of Tumours


Biesele, Poyner and Painter have shown1 that diplochromosomes and higher polytenes are often to be found in tumours and that these large chromosomes are the result of endomitosis. Biesele and Cowdry2 also found these abnormalities in the epidermis of mice painted with methylcholanthrene, as early as two days after painting.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Biesele, J. J., Poyner, H., and Painter, T. S., Univ. Texas Publ. No. 4243 (1942).

  2. 2

    Biesele, J. J., and Cowdry, E. V., J. Nat. Cancer Inst., 4, 373 (1944).

  3. 3

    Guyer, M. F., and Claus, P. E., Proc. Soc. Exp. Biol. and Med., 35, 568 (1936); Anat. Rec., 73, 17 (1937); Cane. Res., 2, 16 (1941).

  4. 4

    Mottram, J. C., "The Problem of Tumours" (London: Lewis and Co., Ltd., 1942).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.