Production of 'Endomitosis' in Bean Roots and its Bearing on the Genesis of Tumours

Abstract

Biesele, Poyner and Painter have shown1 that diplochromosomes and higher polytenes are often to be found in tumours and that these large chromosomes are the result of endomitosis. Biesele and Cowdry2 also found these abnormalities in the epidermis of mice painted with methylcholanthrene, as early as two days after painting.

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References

  1. 1

    Biesele, J. J., Poyner, H., and Painter, T. S., Univ. Texas Publ. No. 4243 (1942).

  2. 2

    Biesele, J. J., and Cowdry, E. V., J. Nat. Cancer Inst., 4, 373 (1944).

  3. 3

    Guyer, M. F., and Claus, P. E., Proc. Soc. Exp. Biol. and Med., 35, 568 (1936); Anat. Rec., 73, 17 (1937); Cane. Res., 2, 16 (1941).

  4. 4

    Mottram, J. C., "The Problem of Tumours" (London: Lewis and Co., Ltd., 1942).

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