Mode of Action of Benzylamine Sulphonamide ('Marfanil')


THE antibacterial agent benzylamine-4-sulphon-amide (I), which under the name of 'Marfanil' was supplied in quantity to Rommel's forces in North Africa, has given interesting results in Allied hands (cf. Mitchell, Rees and Robinson1). Organisms made resistant to sulphanilamide by growing them in contact with the drug were resistant to all other sulphonamides except 'Marfanil'2. Schreuss found that the antibacterial action of 'Marfanil' was not antagonized by p-aminobenzoic acid3. A possible reason for these differences from the sulphanilamide-like drugs is revealed by the determination of the basic strength.

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  1. 1

    Mitchell, G., Rees, W., and Robinson, C., Lancet, 627 (1944).

  2. 2

    Selbie, F., and McIntosh, J., Brit. J. Exper. Path., 24, 246 (1943).

  3. 3

    Schreuss, H., Klin. Wochsch., 21, 671 (1942).

  4. 4

    Albert, A., and Goldacre, R., Nature, 149, 245 (1942).

  5. 5

    Bell, P., and Roblin, R., J. Amer. Chem. Soc., 64, 2905 (1942).

  6. 6

    Albert, A., and Magrath, D., J. Chem. Soc., in the Press.

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