Penicillin in Yaws and Tropical Ulcer


PENICILLIN has not, up to the present, been extensively employed in tropical medicine. There is, however, evidence that, among other conditions, penicillin has an action in syphilis1,2, on Spirochæta recurrentis infections in mice and on Spirillum minus3 as well as possibly on Leptospira icterohæmorrhagiæ4. Evidence which is here presented shows that penicillin is of value in yaws and tropical ulcers, which form two of the greatest problems in tropical medicine. Ulcers during the present year, 1944, have, for example, been responsible for the loss of 30,000 men-days among West African troops.

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  1. 1

    Mahoney, J. F., Arnold, R. C., and Harris, A., Amer. J. Pub. Hlth., 33, 1387 (1943).

  2. 2

    Wise, E. R., and Pillsbury, D. M., Proc. Roy. Soc. Med., Section of Medicine, 30, 11 (1944).

  3. 3

    Lourie, E. M., and Collier, H. O. J., Ann. Trop. Med. and Parasitol., 37, 200 (1943).

  4. 4

    Herrell, W. E., Nichols, D. R., and Heilman, D. H., J. Amer. Med. Assoc., 125, 1003 (1944).

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