An Effect of Overdosage with Corticotrophic Pituitary Extract on the Rat Kidney

Abstract

RECENT progress in the purification of the corticotrophic fraction of the anterior pituitary lobe (the preparations contain 24–48 cortic-lipoid units per mgm.) has made it possible to inject rats with very large doses of this hormone. While investigating the effect of such large doses, it was noticed that the kidneys of animals intraperitoneally injected with a dose exceeding 100 units presented a picture which differed considerably from that of the kidneys of the control rats.

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